3-Acetyl-2-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-Acetyl-2-methylimidazo[1,2-a]pyridine
• CAS No.: 29096-60-4
• Molecular Formula: C10H10 N2 O
• Molecular Weight: 174.202
• Hs Code.: 2933990090
• European Community (EC) Number: 807-310-2
• DSSTox Substance ID: DTXSID90370643
• Nikkaji Number: J2.012.591H
• Wikidata: Q82157771
• ChEMBL ID: CHEMBL1520912
• Mol file: 29096-60-4.mol

Synonyms:29096-60-4;3-Acetyl-2-methylimidazo[1,2-a]pyridine;1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone;Ethanone, 1-(2-methylimidazo[1,2-a]pyridin-3-yl)-;MFCD00665892;1-{2-methylimidazo[1,2-a]pyridin-3-yl}ethan-1-one;ETHANONE,1-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)-;MLS000089898;SCHEMBL196599;CHEMBL1520912;DTXSID90370643;RMDMJJKMOQLKPC-UHFFFAOYSA-N;HMS2507A07;BCP24409;AKOS002382670;CS-W021207;SS-4807;SMR000024516;2-Methyl-3-acetylimidazo[1,2-a]pyridine;FT-0648525;FT-0695569;1R-1190;SR-01000477334;1-(2-methyl-imidazo[1,2-a]pyridin-3-yl)-ethanone;J-511499;SR-01000477334-1;3-Acetyl-2-methylimidazo[1,2-a]pyridine, AldrichCPR;{[4-AMINO-5-(ETHOXYCARBONYL)PYRIMIDIN-2-YL]THIO}ACETICACID

Chemical Property of 3-Acetyl-2-methylimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 112
• PSA: 34.37000
• Density: 1.18g/cm3
• LogP: 1.84530
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 217

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Methylimidazo[1,2-a]pyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CC=CC2=N1)C(=O)C

Technology Process of 3-Acetyl-2-methylimidazo[1,2-a]pyridine

There total 12 articles about 3-Acetyl-2-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-aminopyridine (504-29-0) + acetylacetone (123-54-6,81235-32-7) → 1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone (29096-60-4)

Guidance literature:

With Bromotrichloromethane; potassium hydrogencarbonate; In acetonitrile; at 80 ℃;

DOI:10.1002/adsc.201501012

Reference yield: 87.0%

2-aminopyridine (504-29-0) + 3-chloropentane-2,4-dione (1694-29-7) → 1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone (29096-60-4)

Guidance literature:

With sodium hydrogencarbonate; In 1,2-dimethoxyethane; for 72h; Reflux;

Reference yield: 41.0%

2-aminopyridine (504-29-0) + 3-bromopentane-2,4-dione (3043-28-5) → 1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone (29096-60-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 18h; Heating;

DOI:10.1016/S0960-894X(03)00638-3

upstream raw materials:

2-aminopyridine

3-chloropentane-2,4-dione

benzene

water

Downstream raw materials:

C₁₇H₁₃N₃O₃

C₁₇H₁₃FN₂O

C₁₇H₁₂Cl₂N₂O

Refernces

• 1、 -. "DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS". Paragraph 0083; 00105. . Retrieved 2021/01/29.
• 2、 Bhagat, Saket B.,Telvekar, Vikas N.. "NBS mediated protocol for the synthesis of N-bridged fused heterocycles in water". supporting information. p. 3662 - 3666. Retrieved 2017/08/23.