2,2-DIFLUORO-2-PYRIDIN-2-YLETHANAMINE

Base Information

• Chemical Name: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANAMINE
• CAS No.: 267875-68-3
• Molecular Formula: C7H8 F2 N2
• Molecular Weight: 158.14900
• Mol file: 267875-68-3.mol

Synonyms:2,2-Difluoro-2-(2-pyridyl)ethylamine;2,2-Difluoro-2-(pyridin-2-yl)ethanamine; 2-(2-Pyridyl)-2,2-difluoroethylamine;[2,2-Difluoro-2-(pyridin-2-yl)ethyl]amine

Chemical Property of 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANAMINE

Chemical Property:

• Vapor Pressure: 0.032mmHg at 25°C
• Boiling Point: 243.697oC at 760 mmHg
• PKA: 6.34±0.30(Predicted)
• Flash Point: 101.185oC
• PSA: 38.91000
• Density: 1.208g/cm3
• LogP: 1.83240
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,2-Difluoro-2-pyridin-2-ylethaneamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANAMINE

There total 14 articles about 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-difluoro-2-(pyridin-2-yl)ethylazide (267875-67-2) → 2.2-Difluoro-2-(pyridin-2-yl)ethylamine (267875-68-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 68.0%

2,2-difluoro-2-(pyridin-2-yl)acetonitrile → 2.2-Difluoro-2-(pyridin-2-yl)ethylamine (267875-68-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at -40 ℃; Reflux;

DOI:10.1016/j.jfluchem.2021.109792

Reference yield:

ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate (267876-28-8) → 2.2-Difluoro-2-(pyridin-2-yl)ethylamine (267875-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.02 g / NaBH₄ / methanol / 1 h

2: 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 1 h / -78 °C

3: 50 mg / NaN₃ / dimethylformamide / 1.5 h / 60 °C

4: 1.2 g / H₂ / 10percent Pd/C / ethyl acetate / 1 h

With sodium tetrahydroborate; sodium azide; 2,6-di-tert-butyl-4-methylpyridine; hydrogen; 10percent Pd/C; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm020311f

upstream raw materials:

2,2-difluoro-2-(pyridin-2-yl)ethylazide

ethyl 2-(pyridinyl-2)acetate

ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate

2,2-difluoro-2-(pyridin-2-yl)-ethan-1-ol

Downstream raw materials:

2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt

2-(2,2-difluoro-2-(pyridin-2-yl)ethyl)-3-oxo-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide

{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

Refernces

• 1、 -. "2,6-Diaminopyridine Compounds Suitable For Treating Diseases Associated With Amyloid Or Amyloid-Like Proteins Or For Treating Or Preventing Ocular Diseases Or Conditions Associated With A Pathological Abnormality/Change In The Tissue Of The Visual System". Page/Page column 49. . Retrieved 2011/05/03.
• 2、 -. "2,6-DIAMINOPYRIDINE COMPOUNDS SUITABLE FOR TREATING DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS OR FOR TREATING OR PREVENTING OCULAR DISEASES OR CONDITIONS ASSOCIATED WITH A PATHOLOGICAL ABNORMALITY/CHANGE IN THE TISSUE OF THE VISUAL SYSTEM". Page/Page column 102. . Retrieved 2011/05/05.