4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE

Base Information

• Chemical Name: 4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE
• CAS No.: 29274-23-5
• Molecular Formula: C₆H₅N₃O
• Molecular Weight: 135.125
• Hs Code.: 2933990090
• Mol file: 29274-23-5.mol

Synonyms:Pyrazolo[1,5-a]pyrimidin-7-one;

Chemical Property of 4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.739
• Boiling Point: 297.644 °C at 760 mmHg
• Flash Point: 133.811 °C
• PSA: 50.42000
• Density: 1.511 g/cm³
• LogP: 0.43490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrazolo[1,5-a]pyrimidin-7(4H)-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE

There total 11 articles about 4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid (197367-75-2) → 4,7-dihydropyrazolo<1,5-a>pyrimidin-7-one (29274-23-5)

Guidance literature:

With diphenyl ether-biphenyl eutectic; at 250 ℃; for 2h;

DOI:10.1021/jo062120g

Reference yield: 77.0%

3(5)-aminopyrazole (1225387-53-0) + formic acid ethyl ester (109-94-4) → 4,7-dihydropyrazolo<1,5-a>pyrimidin-7-one (29274-23-5)

Guidance literature:

ethyl acetate; formic acid ethyl ester; With sodium; In toluene; at 20 - 40 ℃; for 16h;

3⁽⁵⁾-aminopyrazole; In ethanol; toluene; for 4h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield: 72.0%

1,3-dimethyluracil (874-14-6,156398-76-4) + 3-aminopyrazole (1820-80-0,916420-28-5) → 4,7-dihydropyrazolo<1,5-a>pyrimidin-7-one (29274-23-5)

Guidance literature:

1,3-dimethyluracil; 3-aminopyrazole; With sodium ethanolate; In ethanol; for 1h; Heating / reflux;

With acetic acid; In ethanol; water; at 0 ℃;

upstream raw materials:

1,3-dimethyluracil

3-aminopyrazole

3⁽⁵⁾-aminopyrazole

ethyl (E)-3-(dimethylamino)acrylate

Downstream raw materials:

3-bromo-7-chloropyrazolo[1,5-a]pyrimidine

(S)-N-(1-(5-Methoxy-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)pyrazolo[1,5-a]pyrimidin-7-amine

7-chloropyrazolo[1,5-a]pyrirnidine

Refernces

• 1、 Gehringer, Matthias,Forster, Michael,Pfaffenrot, Ellen,Bauer, Silke M.,Laufer, Stefan A.. "Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres". supporting information. p. 2516 - 2527. Retrieved 2015/08/24.
• 2、 -. "Pyrazolopyrimidines as protein kinase inhibitors". Page/Page column 21. . Retrieved 2010/11/26.