21-Episerratriol

Base Information

• Chemical Name: 21-Episerratriol
• CAS No.: 24513-57-3
• Molecular Formula: C₃₀H₅₀O₃
• Molecular Weight: 458.725
• Mol file: 24513-57-3.mol

Synonyms:C(14a)-Homo-27-norgammacer-14-ene-3,21,24-triol,(3b,4b,21b)-; C(14a)-Homo-27-norgammacer-14-ene-3b,21b,24-triol (8CI); 1H-Cyclohepta[1,2-a:5,4-a']dinaphthalene-3,11-diol,2,3,4,4a,5,6,6a,7,9,9a,10,11,12,13,13a,13b,14,15,15a,15b-eicosahydro-4-(hydroxymethyl)-4,6a,10,10,13a,15b-hexamethyl-,[3S-(3a,4a,4ab,6aa,9aa,11a,13ab,13ba,15ab,15ba)]-; 21-Episerratriol;3-Epilycoclavanol; Serrat-14-en-3b,21b,24-triol

Chemical Property of 21-Episerratriol

Chemical Property:

• Boiling Point: 566.1±50.0 °C(Predicted)
• PKA: 14.93±0.70(Predicted)
• PSA: 60.69000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 6.11210

Purity/Quality:

98%min ^*data from raw suppliers

21-Episerratriol ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 21-Episerratriol

There total 3 articles about 21-Episerratriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (4S,4aR,6aS,9aR,11R,13aR,13bS,15aS,15bR)-11-acetoxy-4,6a,10,10,13a,15b-hexamethyl-3-oxo-2,3,4,4a,5,6,6a,7,9,9a,10,11,12,13,13a,13b,14,15,15a,15b-icosahydro-1H-cyclohepta[1,2-a;5,4-a']dinaphthalen-4-ylmethyl ester (13828-24-5,13832-36-5) → 21-episerratriol (24513-57-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1248/cpb.22.2383

Reference yield:

Lycoclavanoldiacetat-A (13828-23-4,13832-34-3) → 21-episerratriol (24513-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃, aq. H₂SO₄ / acetone

2: LiAlH₄ / tetrahydrofuran

With chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; acetone;

DOI:10.1248/cpb.22.2383

Reference yield:

lycoclavanol triacetate (13828-16-5) → 21-episerratriol (24513-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOMe / methanol

2: CrO₃, aq. H₂SO₄ / acetone

3: LiAlH₄ / tetrahydrofuran

With chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; sodium methylate; In tetrahydrofuran; methanol; acetone;

DOI:10.1248/cpb.22.2383

upstream raw materials:

Acetic acid (4S,4aR,6aS,9aR,11R,13aR,13bS,15aS,15bR)-11-acetoxy-4,6a,10,10,13a,15b-hexamethyl-3-oxo-2,3,4,4a,5,6,6a,7,9,9a,10,11,12,13,13a,13b,14,15,15a,15b-icosahydro-1H-cyclohepta[1,2-a;5,4-a']dinaphthalen-4-ylmethyl ester

Lycoclavanoldiacetat-A

lycoclavanol triacetate

Refernces