(R)-2-Phenylpiperazine

Base Information

• Chemical Name: (R)-2-Phenylpiperazine
• CAS No.: 137766-76-8
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• Mol file: 137766-76-8.mol

Synonyms:

Chemical Property of (R)-2-Phenylpiperazine

Chemical Property:

• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 169 °C
• Density: 0.997g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Phenylpiperazine

There total 5 articles about (R)-2-Phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-phenylpiperazine-2,5-dione (81554-02-1) → (R)-2-phenylpiperazine (137766-76-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 70 ℃; for 0.5h;

Reference yield:

(R)-2-phenyl-1,4-bis(p-toluenesulphonyl)piperazine + phenol (108-95-2,27073-41-2) → (R)-2-phenylpiperazine (137766-76-8)

Guidance literature:

With sodium hydroxide; In water; hydrogen bromide; ethyl acetate;

Reference yield:

phenylglyoxal hydrate (1074-12-0) + ethylenediamine (107-15-3,85404-18-8) → (R)-2-phenylpiperazine (137766-76-8)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride; In aq. phosphate buffer; at 25 ℃; for 4h; pH=7; Enzymatic reaction;

DOI:10.1021/acscatal.8b00291

upstream raw materials:

phenol

(R)-3-phenylpiperazine-2,5-dione

phenylglyoxal hydrate

ethylenediamine

Downstream raw materials:

C₂₁H₂₁N₅O

Refernces

• 1、 -. "Histone demethylase LSD1 (lysine specific demethylase 1) inhibitor". . . Retrieved 2017/09/29.