Technology Process of 6-BROMO-2,3-DIHYDROBENZOFURAN-3-AMINE HYDROCHLORIDE
There total 4 articles about 6-BROMO-2,3-DIHYDROBENZOFURAN-3-AMINE HYDROCHLORIDE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(rac)-3-azido-6-bromo-2,3-dihydrobenzofuran;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
potassium hydroxide;
In
water;
at 55 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 1.75 h / 0 - 20 °C
2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 0 - 15 °C / Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 1 h / 20 °C
3.2: 5 h / 55 °C
With
diphenyl phosphoryl azide; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 0 - 15 °C / Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / 1 h / 20 °C
2.2: 5 h / 55 °C
With
diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine;
In
tetrahydrofuran; toluene;
