2-Fluoro-5-methylphenylacetic acid

Base Information

• Chemical Name: 2-Fluoro-5-methylphenylacetic acid
• CAS No.: 203314-27-6
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.16
• Hs Code.: 2916399090
• European Community (EC) Number: 681-489-3
• DSSTox Substance ID: DTXSID00590638
• Wikidata: Q72474761
• Mol file: 203314-27-6.mol

Synonyms:2-Fluoro-5-methylphenylacetic acid;203314-27-6;2-(2-fluoro-5-methylphenyl)acetic acid;Benzeneacetic acid, 2-fluoro-5-methyl-;(2-FLUORO-5-METHYLPHENYL)ACETIC ACID;MFCD06660230;SCHEMBL868718;DTXSID00590638;CQFSSMCJXPLZAT-UHFFFAOYSA-N;CK1027;AKOS002392937;2-(2-fluoro-5-methylphenyl)aceticacid;AS-18810;DB-066144;CS-0128338;EN300-246914;A879711;J-509459;Z982130030

Chemical Property of 2-Fluoro-5-methylphenylacetic acid

Chemical Property:

• Vapor Pressure: 0.00246mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 275.5 °C at 760 mmHg
• PKA: 4.02±0.10(Predicted)
• Flash Point: 120.4 °C
• PSA: 37.30000
• Density: 1.224g/cm³
• LogP: 1.76120
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 168.05865769
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-5-methylphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)F)CC(=O)O

Technology Process of 2-Fluoro-5-methylphenylacetic acid

There total 1 articles about 2-Fluoro-5-methylphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(2-fluoro-5-methylphenyl)acetate → 2-(2-fluoro-5-methylphenyl)acetic acid (203314-27-6)

Guidance literature:

Reference yield:

2-(2-fluoro-5-methylphenyl)acetic acid (203314-27-6) → C9H8BrFO2

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In dichloromethane; for 12h; Reflux;

Reference yield:

methanol (67-56-1) + 2-(2-fluoro-5-methylphenyl)acetic acid (203314-27-6) → methyl 2-(2-fluoro-5-methylphenyl)acetate

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 2h;

Downstream raw materials:

2-(5-(bromomethyl)-2-fluorophenyl)ethanol

(9-(4-fluoro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Refernces