5,7-Dichloro-2,3-dihydroinden-1-one

Base Information

• Chemical Name: 5,7-Dichloro-2,3-dihydroinden-1-one
• CAS No.: 448193-94-0
• Molecular Formula: C9H6Cl2O
• Molecular Weight: 201.0493
• Hs Code.: 2914700090
• Mol file: 448193-94-0.mol

Synonyms:5, 7-Dichloro-2, 3-dihydro-1H-inden-1-one;

Chemical Property of 5,7-Dichloro-2,3-dihydroinden-1-one

Chemical Property:

• Melting Point: 102-106 °C
• Boiling Point: 340.253 °C at 760 mmHg
• Flash Point: 143.559 °C
• PSA: 17.07000
• Density: 1.447 g/cm³
• LogP: 3.12230
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5,7-Dichloro-2,3-dihydro-1H-inden-1-oneICHLORO-2,3-DIHYDRO-1H-INDEN-1-ONE ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-52/53
• Safety Statements: 26-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5,7-Dichloro-1-indanone is used as an organic chemical synthesis intermediate.

Technology Process of 5,7-Dichloro-2,3-dihydroinden-1-one

There total 8 articles about 5,7-Dichloro-2,3-dihydroinden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(3',5'-dichlorophenyl)propanoic acid (95333-95-2) → 5,7-dichloro-2,3-dihydro-1H-inden-1-one (448193-94-0)

Guidance literature:

With chlorosulfonic acid; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2006.10.065

Reference yield: 41.0%

→ 5,7-dichloro-2,3-dihydro-1H-inden-1-one (448193-94-0)

Guidance literature:

With thionyl chloride; In benzene; Reflux;

With aluminum (III) chloride; In 1,2-dichloro-ethane; for 24h;

With aluminum (III) chloride; sodium chloride; at 130 - 180 ℃;

Reference yield:

3,5-dichlorobenzaldehyde (10203-08-4) → 5,7-dichloro-2,3-dihydro-1H-inden-1-one (448193-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / triethylammonium formate

2: 100 percent / H₂O / acetonitrile / 0.5 h / 120 °C / microwave irradiation

3: 99 percent / chlorosulfonic acid / 1 h / 0 °C

With chlorosulfonic acid; water; triethylammonium formate; In acetonitrile; 3: Friedel-Crafts reaction;

DOI:10.1016/j.tet.2006.10.065

upstream raw materials:

3-(2,4-dichlorophenyl)propionic acid

3-(3',5'-dichlorophenyl)propanoic acid

5-(3,5-dichloro-benzyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

3,5-dichlorobenzaldehyde

Refernces

• 1、 Sharma, Anil K.,Subramani, Amutha V.,Gorman, Christopher B.. "Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions". . p. 389 - 395. Retrieved 2007/10/03.
• 2、 -. "Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives". . . Retrieved 2008/06/13.