[Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13)

Base Information

• Chemical Name: [Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13)
• CAS No.: 1314096-87-1
• Molecular Formula: C₃₇H₅₀N₁₀O₁₀S
• Molecular Weight: 826.931
• Mol file: 1314096-87-1.mol

Synonyms:

Chemical Property of [Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13)

There total 1 articles about [Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid (159610-89-6) + 1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine (1314096-75-7) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) → [Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13) (1314096-87-1)

Guidance literature:

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine; With piperidine; Fmoc-Rink-(4-methylbenzhydrylamine) resin; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; solid phase reaction;

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; for 0.0833333h; solid phase reaction;

6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid; 1-(tert-butoxycarbonyl)-L-proline; Fmoc-Ser(tBu)-OH; Fmoc-Tyr(tBu)-OH; Further stages;

DOI:10.1039/c1ob05253e

Reference yield:

[Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13) (1314096-87-1) + Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH) (1314096-88-2) → Fmoc-IC(N-acetamidomethyl)C(N-methyl-phenacyloxycarbamidomethyl)NPAC(N-acetamidomethyl)GPK(N3)YSC(N-methyl-phenacyloxycarbamidomethyl)-NH2 (1314096-89-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1039/c1ob05253e

upstream raw materials:

6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid

1-(tert-butoxycarbonyl)-L-proline

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine

Fmoc-Ser(tBu)-OH

Downstream raw materials:

Fmoc-IC(N-acetamidomethyl)C(N-methyl-phenacyloxycarbamidomethyl)NPAC(N-acetamidomethyl)GPK(N₃)YSC(N-methyl-phenacyloxycarbamidomethyl)-NH₂

Refernces