Pyridine-4-sulfonyl Chloride

Base Information

• Chemical Name: Pyridine-4-sulfonyl Chloride
• CAS No.: 134479-04-2
• Molecular Formula: C5H4ClNO2S
• Molecular Weight: 177.611
• DSSTox Substance ID: DTXSID10468975
• Nikkaji Number: J2.492.129H
• Wikidata: Q72503995
• Mol file: 134479-04-2.mol

Synonyms:Pyridine-4-sulfonyl Chloride;134479-04-2;4-PYRIDINESULFONYL CHLORIDE;4-pyridylsulfonylchloride;4-pyridylsulfonyl chloride;4 -pyridylsulfonyl chloride;SCHEMBL1134359;DTXSID10468975;NHMOJCOXIZRTRR-UHFFFAOYSA-N;BCP25443;AKOS005137886;AM91989;BB 0261297;CS-0103670;FT-0648945;EN300-148196;A856013;[2-(BENZOTHIAZOL-2-YLAMINO)-5-OXO-4,5-DIHYDRO-3H-IMIDAZOL-4-YL]-ACETICACID;PYRIDINE-4-SULFONYL CHLORIDE 4-pyridyl sulfonyl chloride 4-Pyridinesulfonyl chloride PYRIDINE-4-SULFONYL CHLORIDE HCl

Chemical Property of Pyridine-4-sulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 284.162 °C at 760 mmHg
• PKA: -0.61±0.26(Predicted)
• Flash Point: 125.657 °C
• PSA: 55.41000
• Density: 1.489 g/cm³
• LogP: 2.08990
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.9651272
• Heavy Atom Count: 10
• Complexity: 190

Purity/Quality:

98%,99%, ^*data from raw suppliers

pyridine-4-sulfonylchloride 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1S(=O)(=O)Cl

Technology Process of Pyridine-4-sulfonyl Chloride

There total 3 articles about Pyridine-4-sulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

pyridine-4-thiol (4556-23-4) → pyridine-4-sulfonyl chloride (134479-04-2)

Guidance literature:

With sodium hypochlorite; sulfuric acid; sodium chloride; In water; at -15 - 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm300752n

Reference yield:

dipyridin-4-yl disulfide (2645-22-9) → pyridine-4-sulfonyl chloride (134479-04-2)

Guidance literature:

With hydrogenchloride; chlorine; at -10 - -8 ℃; for 0.5h;

DOI:10.3987/COM-07-11088

Reference yield:

4-bromopyridin (1120-87-2) → pyridine-4-sulfonyl chloride (134479-04-2)

Guidance literature:

4-bromopyridin; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; at -10 ℃; Inert atmosphere;

With sulfuryl dichloride; In tetrahydrofuran; toluene; at -10 - 10 ℃;

DOI:10.1055/s-0030-1259953

upstream raw materials:

dipyridin-4-yl disulfide

pyridine-4-thiol

4-bromopyridin

Downstream raw materials:

pyridine-4-sulfonamide

sodium pyridine-4-sulfinate

C₃₈H₄₉F₂N₅O₇S

C₂₈H₂₄N₁₀O₆S₅

Refernces

• 1、 -. "2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE". Page/Page column 206. . Retrieved 2021/06/26.
• 2、 -. "HEPATITIS B VIRAL ASSEMBLY EFFECTORS". Paragraph 00207. . Retrieved 2016/10/31.