6-METHOXYISOQUINOLIN-1-OL

Base Information

• Chemical Name: 6-METHOXYISOQUINOLIN-1-OL
• CAS No.: 26829-43-6
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2933790090
• Mol file: 26829-43-6.mol

Synonyms:6-Methoxy-isoquinolin-1-ol;6-methoxy-2H-isoquinoline-1-one;6-methoxyisoquinolone;6-Methoxy-isocarbostyril;

Chemical Property of 6-METHOXYISOQUINOLIN-1-OL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 180 °C
• Boiling Point: 438.478oC at 760 mmHg
• PKA: 12.79±0.20(Predicted)
• Flash Point: 218.984oC
• PSA: 42.35000
• Density: 1.199g/cm3
• LogP: 1.94900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Methoxyisoquinolin-1(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXYISOQUINOLIN-1-OL

There total 28 articles about 6-METHOXYISOQUINOLIN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

(E)-4-methoxy-2-methylbenzoyl-(N,N-dimethyl)formamidine (900174-96-1) → 6-methoxy-2H-isoquinolin-1-one (26829-43-6)

Guidance literature:

(E)-4-methoxy-2-methylbenzoyl-(N,N-dimethyl)formamidine; With potassium tert-butylate; In tetrahydrofuran; at 60 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 30 ℃; pH=7;

Reference yield: 93.6%

4-methoxy-2-methylbenzoyl(N,N-dimethyl)formamidine (948992-34-5) → 6-methoxy-2H-isoquinolin-1-one (26829-43-6)

Guidance literature:

4-methoxy-2-methylbenzoyl(N,N-dimethyl)formamidine; With potassium tert-butylate; In tetrahydrofuran; at 60 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; at 30 ℃; pH=7;

Reference yield: 87.2%

(E)-3-(3-methoxyphenyl)acryloyl azide (872496-89-4) → 6-methoxy-2H-isoquinolin-1-one (26829-43-6)

Guidance literature:

With tributyl-amine; In diphenylether; at 200 - 230 ℃; for 4h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

trans-3-methoxycinnamic acid

chloroformic acid ethyl ester

(E)-3-(3-methoxyphenyl)acryloyl azide

6-methoxyisoquinoline 2-oxide

Downstream raw materials:

1-chloro-6-methoxyisoquinoline

SAR-407899

4-bromo-6-methoxyisoquinolin-1(2H)-one

4-bromo-1-chloro-6-methoxyisoquinoline

Refernces

• 1、 -. "SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME". Page/Page column 278; 279. . Retrieved 2020/07/07.
• 2、 -. "Aromatic compounds and preparation method and application thereof". Paragraph 0012; 0037-0039; 0071-0073. . Retrieved 2020/02/19.