2-Fluoro-5-hydroxybenzenecarbonitrile

Base Information

• Chemical Name: 2-Fluoro-5-hydroxybenzenecarbonitrile
• CAS No.: 104798-53-0
• Molecular Formula: C7H4FNO
• Molecular Weight: 137.113
• Hs Code.: 2926909090
• Mol file: 104798-53-0.mol

Synonyms:2-Fluoro-5-hydroxybenzenecarbonitrile;2-Fluoro-5-hydroxybenzonitrile 98%;2-Fluoro-5-hydroxybenzonitrile;3-Cyano-4-fluorophenol;Benzonitrile, 2-fluoro-5-hydroxy-

Chemical Property of 2-Fluoro-5-hydroxybenzenecarbonitrile

Chemical Property:

• Vapor Pressure: 0.00473mmHg at 25°C
• Melting Point: 111-113 °C
• Refractive Index: 1.558
• Boiling Point: 268.2 °C at 760 mmHg
• PKA: 8.59±0.18(Predicted)
• Flash Point: 116 °C
• PSA: 44.02000
• Density: 1.34 g/cm³
• LogP: 1.40298
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-5-hydroxybenzenecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-5-hydroxybenzenecarbonitrile

There total 5 articles about 2-Fluoro-5-hydroxybenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,4-difluorocyclohexa-2,5-dienone (42539-98-0) → 2-fluoro-5-hydroxybenzenecarbonitrile (104798-53-0)

Guidance literature:

In N-methyl-acetamide;

Reference yield: 90.0%

4,4-difluorocyclohexa-2,5-dienone (42539-98-0) + potassium cyanide (151-50-8) → 2-fluoro-5-hydroxybenzenecarbonitrile (104798-53-0)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield: 61.0%

2-fluoro 5-methoxybenzonitrile (127667-01-0) → 2-fluoro-5-hydroxybenzenecarbonitrile (104798-53-0)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 48h;

upstream raw materials:

4,4-difluorocyclohexa-2,5-dienone

potassium cyanide

benzene

phenol

Downstream raw materials:

5-(benzyloxy)-2-fluorobenzonitrile

5-ethoxy-2-fluorobenzonitrile

6-benzyloxy-quinazoline-2,4-diamine

2,4-diaminoquinazolin-6-yl 2,5-dimethoxybenzoate

Refernces

• 1、 -. "2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES". Page/Page column 23. . Retrieved 2009/01/24.
• 2、 -. "Preparation of 3-cyano-4-fluorophenol". . . Retrieved 2008/06/13.