GAMMA-METHYL-L-LEUCINE

Base Information

• Chemical Name: GAMMA-METHYL-L-LEUCINE
• CAS No.: 106247-35-2
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.202
• Hs Code.: 2922498590
• Mol file: 106247-35-2.mol

Synonyms:(S)-2-AMINO-4,4-DIMETHYLPENTANOIC ACID;T-BUTYL-L-ALANINE;NEOPENTYLGLYCINE;4-METHYL-LEUCINE;4-METHYL-L-LEUCINE;(-)-2-AMINO-4,4-DIMETHYLPENTANOIC ACID;L-ALPHA-NEOPENTYLGLYCINE;L-GAMMA-METHYLLEUCINE

Chemical Property of GAMMA-METHYL-L-LEUCINE

Chemical Property:

• Melting Point: 272-274 °C (dec.)
• Boiling Point: 236.0±23.0℃ (760 Torr)
• PKA: 2.56±0.23(Predicted)
• Flash Point: 96.5±22.6℃
• PSA: 63.32000
• Density: 1.016±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.53480
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4,4-dimethylpentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-4,4-dimethylpentanoic Acid is an unnatural amino acid used in vitro biological study of highly modified macrocyclic peptide analogs that act as tight binding inhibitors of thrombin.

Technology Process of GAMMA-METHYL-L-LEUCINE

There total 16 articles about GAMMA-METHYL-L-LEUCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-formyl-D-neopentylglycine (88319-40-8,88319-41-9,88319-42-0) → D-neopentylglycine (57224-50-7,60122-72-7,88319-43-1,106247-35-2)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 2h;

Reference yield: 100.0%

N-formyl-L-neopentylglycine (88319-40-8,88319-41-9,88319-42-0) → L-neopentylglycine (57224-50-7,60122-72-7,88319-43-1,106247-35-2)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 2h;

Reference yield:

(E)-2-cyano-4,4-dimethyl-pent-2-enoic acid (39168-28-0) → L-neopentylglycine (57224-50-7,60122-72-7,88319-43-1,106247-35-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / H₂ / palladium black / acetic acid / 11.5 h

2: 50 percent / H₂O₂ / aq. KOH / 2 h

3: 100 percent / Br₂/aq. NaOH / 2 h / 30 - 40 °C

4: Ac₂O / 2 h / 0 - 5 °C

5: 100 percent / 10percent Aq_.HBr / 2 h / 100 °C

With sodium hydroxide; hydrogen bromide; hydrogen; dihydrogen peroxide; bromine; acetic anhydride; palladium; In potassium hydroxide; acetic acid;

upstream raw materials:

N-formyl-D-neopentylglycine

(E)-2-cyano-4,4-dimethyl-pent-2-enoic acid

3,3-dimethylbutyrylaldehyde

3,3-dimethylbutanoic acid chloride

Downstream raw materials:

acetyl-L-neopentylglycine

N-2-nitrobenzenesulfenyl-L-neopentylglycine

N-benzoyloxycarbonyl-L-neopentylglycine

Refernces