O-(2-tert-butoxyethyl)hydroxylaMine

Base Information

• Chemical Name: O-(2-tert-butoxyethyl)hydroxylaMine
• CAS No.: 1023742-13-3
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.191
• Mol file: 1023742-13-3.mol

Synonyms:(2-(tert-Butoxy)ethoxy)amine;O-(2-tert-Butoxyethyl)hydroxylamine;O-(2-tert-Butylethyl)hydroxyamine;

Chemical Property of O-(2-tert-butoxyethyl)hydroxylaMine

Chemical Property:

• Boiling Point: 186.481 °C at 760 mmHg
• PKA: 4.28±0.70(Predicted)
• Flash Point: 63.873 °C
• PSA: 44.48000
• Density: 0.925 g/cm³
• LogP: 1.39210

Purity/Quality:

99.9% ^*data from raw suppliers

O-(2-tert-Butoxy-ethyl)-hydroxylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-(2-tert-butoxyethyl)hydroxylaMine

There total 2 articles about O-(2-tert-butoxyethyl)hydroxylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(2-tert-butoxy-ethoxy)-isoindole-1,3-dione (870243-67-7) → O-(2-(tert-butoxy)ethyl)hydroxylamine (1023742-13-3)

Guidance literature:

With ammonia; In ethanol; under 912.061 Torr;

Reference yield:

tert-butyl glycidyl ether (7580-85-0) → O-(2-(tert-butoxy)ethyl)hydroxylamine (1023742-13-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tert-butyl methyl ether / 2 h / 0 - 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 80 °C

3: ammonia / ethanol / 912.06 Torr

With ammonia; sodium hydrogencarbonate; triethylamine; In ethanol; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield: 88.0%

O-(2-(tert-butoxy)ethyl)hydroxylamine (1023742-13-3) + 2,3,4-trifluoro-5-nitro-benzoic acid (197520-71-1) → N-(2-tert-butoxyethoxy)-2,3,4-trifluoro-5-nitrobenzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 8h; Reagent/catalyst; Solvent; Temperature; Green chemistry;

upstream raw materials:

2-(2-tert-butoxy-ethoxy)-isoindole-1,3-dione

tert-butyl glycidyl ether

Downstream raw materials:

N-(2-tert-butoxyethoxy)-6-(2-chloro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

N-(2-tert-butoxyethoxy)-3-ethyl-6-(2-fluoro-4-iodophenylamino)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

3-(2-tert-butoxyethoxy)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

6-fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-tert-butoxy-ethoxy)-amide

Refernces

• 1、 -. "KINASE INHIBITORS AS THERAPEUTIC AGENTS". Page/Page column 293. . Retrieved 2010/02/14.