(S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate

Base Information

• Chemical Name: (S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate
• CAS No.: 1052703-81-7
• Molecular Formula: C₁₃H₂₇NO₂
• Molecular Weight: 229.363
• Hs Code.: 2922499990
• Mol file: 1052703-81-7.mol

Synonyms:(S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate

Chemical Property of (S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate

Chemical Property:

• Boiling Point: 274oC
• Flash Point: 120 ºC
• PSA: 38.33000
• Density: 0.896
• LogP: 2.99080
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Methyl2-((3,3-dimethylbutyl)amino)-3,3-dimethylbutanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate

There total 1 articles about (S)-Methyl 2-(3,3-dimethylbutylamino)-3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethylbutyrylaldehyde (2987-16-8) + L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0) → (S)-2-(3,3-Dimethyl-butylamino)-3,3-dimethyl-butyric acid methyl ester (1052703-81-7)

Guidance literature:

With sodium cyanoborohydride; triethylamine; In methanol; at 20 ℃; for 72h;

DOI:10.1021/ol052371w

upstream raw materials:

3,3-dimethylbutyrylaldehyde

L-tert-leucine methyl ester hydrochloride

Refernces

• 1、 Fitch, Duke M.,Evans, Karen A.,Chai, Deping,Duffy, Kevin J.. "A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase". . p. 5521 - 5524. Retrieved 2007/10/03.