Technology Process of N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
There total 4 articles about N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2BrH*C11H11N5S2;
With
triethylamine;
In
acetonitrile;
at 54.5 ℃;
for 2.25h;
m-chlorophenyl isocyanate;
In
acetonitrile;
at 50 ℃;
for 5.38333h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 5.87 h / 20 °C
2.1: bromine / acetic acid / 3.93 h / 50 - 55 °C
3.1: ethanol; water / 3.17 h / 78 °C
4.1: triethylamine / acetonitrile / 2.25 h / 54.5 °C
4.2: 5.38 h / 50 °C
With
hydrogenchloride; bromine; triethylamine;
In
ethanol; water; acetic acid; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / acetic acid / 3.93 h / 50 - 55 °C
2.1: ethanol; water / 3.17 h / 78 °C
3.1: triethylamine / acetonitrile / 2.25 h / 54.5 °C
3.2: 5.38 h / 50 °C
With
bromine; triethylamine;
In
ethanol; water; acetic acid; acetonitrile;
