pteroyl-S-propylhomocysteine sulfoximine

Base Information

• Chemical Name: pteroyl-S-propylhomocysteine sulfoximine
• CAS No.: 115453-78-6
• Molecular Formula: C₂₁H₂₆N₈O₅S
• Molecular Weight: 502.554
• Mol file: 115453-78-6.mol

Synonyms:

Chemical Property of pteroyl-S-propylhomocysteine sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pteroyl-S-propylhomocysteine sulfoximine

There total 2 articles about pteroyl-S-propylhomocysteine sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-prothionine (SR)-sulfoximine (70085-86-8) → pteroyl-S-propylhomocysteine sulfoximine (115453-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86.1 percent / concd. HCl / methanol / 48 h / Ambient temperature

2: 1.) Et₃N, i-BuOCOCl, 2.) Et₃N / 1.) DMSO, RT, 45 min, 2.) 30-35 deg C, 24 h

With hydrogenchloride; triethylamine; isobutyl chloroformate; In methanol;

DOI:10.1021/jm00085a010

Reference yield:

N10-trifluoroacetylpteroic acid (37793-53-6) + methyl DL-2-amino-4-butanoate dihydrochloride (139895-39-9) → pteroyl-S-propylhomocysteine sulfoximine (115453-78-6)

Guidance literature:

With triethylamine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) DMSO, RT, 45 min, 2.) 30-35 deg C, 24 h;

DOI:10.1021/jm00085a010

upstream raw materials:

N₁₀-trifluoroacetylpteroic acid

methyl DL-2-amino-4-butanoate dihydrochloride

DL-prothionine (SR)-sulfoximine

Refernces