4H-1,2,4-Triazole-4-ethanamine

Base Information

• Chemical Name: 4H-1,2,4-Triazole-4-ethanamine
• CAS No.: 1008526-84-8
• Molecular Formula: C4H8N4
• Molecular Weight: 112.1331
• Hs Code.: 2933990090
• Mol file: 1008526-84-8.mol

Synonyms:4H-1,2,4-Triazole-4-ethanamine;2-(4H-1,2,4-TRIAZOL-4-YL)ETHANAMINE;2-(4H-1,2,4-triazol-4-yl)ethanamine(SALTDATA: 2HCl)

Chemical Property of 4H-1,2,4-Triazole-4-ethanamine

Chemical Property:

• Boiling Point: 266.3 °C at 760 mmHg
• PKA: 7.38±0.10(Predicted)
• Flash Point: 114.9 °C
• PSA: 56.73000
• Density: 1.31 g/cm³
• LogP: -0.06290
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-(1,2,4-triazol-4-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1,2,4-Triazole-4-ethanamine

There total 1 articles about 4H-1,2,4-Triazole-4-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,2,4-Triazole (288-88-0,63598-71-0) + chloroethylamine (689-98-5) → 2-[1,2,4]triazol-4-yl-ethylamine (1008526-84-8)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In 1,4-dioxane; benzene; at 75 ℃; for 2h;

Reference yield: 82.5%

tert-butyl N-[[6-[2-chloro-3-[2-chloro-3-(3-formyl-4-oxopyrido[1,2-a]pyrimidin-8-yl)phenyl]phenyl]-2-methoxy-3-pyridyl]methyl]-N-[[(2S)-5-oxopyrrolidin-2-yl]methyl]carbamate + 2-[1,2,4]triazol-4-yl-ethylamine (1008526-84-8) → tert-butyl N-[[6-[2-chloro-3-[2-chloro-3-[4-oxo-3-[[2-(1,2,4-triazol-4-yl)ethylamino]methyl]pyrido[1,2-a]pyrimidin-8-yl]phenyl]phenyl]-2-methoxy-3-pyridyl]methyl]-N-[[(2S)-5-oxopyrrolidin-2-yl]methyl]carbamate

Guidance literature:

tert-butyl N-[[6-[2-chloro-3-[2-chloro-3-(3-formyl-4-oxopyrido[1,2-a]pyrimidin-8-yl)phenyl]phenyl]-2-methoxy-3-pyridyl]methyl]-N-[[(2S)-5-oxopyrrolidin-2-yl]methyl]carbamate; 2-[1,2,4]triazol-4-yl-ethylamine; With acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With sodium cyanoborohydride; In tetrahydrofuran; methanol; for 2h;

Reference yield:

C30H19Cl2F5N4O5S + 2-[1,2,4]triazol-4-yl-ethylamine (1008526-84-8) → C28H26Cl2N8O4S

Guidance literature:

With N-ethylmorpholine;; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.1c01601

upstream raw materials:

1,2,4-Triazole

chloroethylamine

Refernces