N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide

Base Information

• Chemical Name: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide
• CAS No.: 1169699-63-1
• Molecular Formula: C15H21ClN2O2
• Molecular Weight: 296.79
• Hs Code.: 2933399090
• Mol file: 1169699-63-1.mol

Synonyms:N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide

Chemical Property of N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide

Chemical Property:

• PSA: 56.06000
• LogP: 2.14670
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-((1-Benzyl-4-hydroxypiperidin-4-yl)methyl)-2-chloroacetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide

There total 3 articles about N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-(aminomethyl)-1-benzyl-4-hydroxypiperidine (23804-68-4) + chloroacetyl chloride (79-04-9) → N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide (1169699-63-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.916667h; Inert atmosphere;

Reference yield:

N-benzyl-1-oxa-6-azaspiro[2,5]-octane (19867-34-6) → N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide (1169699-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol; water / 0 - 20 °C

2: triethylamine / dichloromethane / 0.92 h / 0 °C / Inert atmosphere

With ammonium hydroxide; triethylamine; In methanol; dichloromethane; water; 2: |Schotten-Baumann Reaction;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide (1169699-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 1.17 h / 10 - 20 °C / Cooling with ice

1.2: 1.5 h / 20 °C

2.1: ammonium hydroxide / methanol; water / 0 - 20 °C

3.1: triethylamine / dichloromethane / 0.92 h / 0 °C / Inert atmosphere

With ammonium hydroxide; sodium hydride; triethylamine; In methanol; dichloromethane; water; dimethyl sulfoxide; mineral oil; 3.1: |Schotten-Baumann Reaction;

upstream raw materials:

1-phenylmethyl-4-piperidone

4-(aminomethyl)-1-benzyl-4-hydroxypiperidine

chloroacetyl chloride

N-benzyl-1-oxa-6-azaspiro[2,5]-octane

Downstream raw materials:

tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate

Refernces

• 1、 -. "2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD)". . . Retrieved 2016/04/09.