2-Fluoro-5-methylpyridine-3-boronic acid

Base Information

• Chemical Name: 2-Fluoro-5-methylpyridine-3-boronic acid
• CAS No.: 1072952-45-4
• Molecular Formula: C6H7BFNO2
• Molecular Weight: 154.936
• Hs Code.: 2933399990
• Mol file: 1072952-45-4.mol

Synonyms:Boronic acid, B-(2-fluoro-5-methyl-3-pyridinyl)-;

Chemical Property of 2-Fluoro-5-methylpyridine-3-boronic acid

Chemical Property:

• Boiling Point: 344.457 °C at 760 mmHg
• Flash Point: 162.122 °C
• PSA: 53.35000
• Density: 1.282 g/cm³
• LogP: -0.79110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-methylpyridine-3-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-5-methylpyridine-3-boronic acid

There total 2 articles about 2-Fluoro-5-methylpyridine-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H19BFNO2 → 2-fluoro-5-methylpyridin-3-ylboronic acid (1072952-45-4)

Guidance literature:

C₁₂H₁₉BFNO₂; With sodium hydroxide; In tetrahydrofuran; water; at 22 ℃; pH=10;

With hydrogenchloride; In water;

DOI:10.1021/jm300184s

Reference yield:

2-fluoro-5-methylpyridine (2369-19-9) → 2-fluoro-5-methylpyridin-3-ylboronic acid (1072952-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 22 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 22 °C / pH 10

With sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; water;

DOI:10.1021/jm300184s

Reference yield: 47.0%

2-fluoro-5-methylpyridin-3-ylboronic acid (1072952-45-4) + 8-bromo-1-(3,5-dichlorophenyl)-7-methoxy-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylic acid → 1-(3,5-dichlorophenyl)-8-(2-fluoro-5-methylpyridin-3-yl)-7-methoxy-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylic acid

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; In 1,4-dioxane; water; at 90 ℃; for 2h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

2-fluoro-5-methylpyridine

Refernces