6-Iodo-2,3-dimethoxypyridine

Base Information

• Chemical Name: 6-Iodo-2,3-dimethoxypyridine
• CAS No.: 321535-23-3
• Molecular Formula: C7H8INO2
• Molecular Weight: 265.051
• Hs Code.: 2933399090
• Mol file: 321535-23-3.mol

Synonyms:6-IODO-2,3-DIMETHOXYPYRIDINE

Chemical Property of 6-Iodo-2,3-dimethoxypyridine

Chemical Property:

• Boiling Point: 274.7 °C at 760 mmHg
• PKA: -1.30±0.10(Predicted)
• Flash Point: 119.9 °C
• PSA: 31.35000
• Density: 1.735 g/cm³
• LogP: 1.70340
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Iodo-2,3-dimethoxypyridine Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Iodo-2,3-dimethoxypyridine

There total 2 articles about 6-Iodo-2,3-dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

sodium methylate (124-41-4) + 2-bromo-6-iodo-3-methoxypyridine (321535-37-9) → 2,3-dimethoxy-6-iodo-pyridine (321535-23-3,1138444-04-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

methanol (67-56-1) + sodium methylate (124-41-4) + 2-bromo-6-iodo-3-methoxypyridine (321535-37-9) → 2,3-dimethoxy-6-iodo-pyridine (321535-23-3,1138444-04-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h;

Reference yield: 68.0%

phenylmethanethiol (100-53-8) + 2,3-dimethoxy-6-iodo-pyridine (321535-23-3,1138444-04-8) → 6-(benzylsulfanyl)-2,3-dimethoxypyridine (1417710-71-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 120 ℃; for 2h; Microwave irradiation;

upstream raw materials:

sodium methylate

2-bromo-6-iodo-3-methoxypyridine

methanol

Downstream raw materials:

5,6-dimethoxypyridine-2-carbonitrile

5,6-dimethoxypicolinaldehyde

5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine

3-bromo-5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine

Refernces

• 1、 -. "A 5, 6 - dimethoxy -2 - picolinic acid synthesis method". Paragraph 0009. . Retrieved 2019/02/13.
• 2、 -. "TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 17-18. . Retrieved 2010/03/02.