1-(1-Methylethyl)azetidin-3-ol

Base Information

• Chemical Name: 1-(1-Methylethyl)azetidin-3-ol
• CAS No.: 13156-06-4
• Molecular Formula: C6H13NO
• Molecular Weight: 115.10
• Hs Code.: 2933990090
• Mol file: 13156-06-4.mol

Synonyms:1-(Propan-2-yl)azetidin-3-ol;3-Azetidinol, 1-(1-methylethyl)-;3-Azetidinol, 1-isopropyl-;

Chemical Property of 1-(1-Methylethyl)azetidin-3-ol

Chemical Property:

• Boiling Point: 155.1 °C at 760 mmHg
• Flash Point: 42.6 °C
• PSA: 23.47000
• Density: 1.036 g/cm³
• LogP: 0.00920
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Isopropylazetidin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-Methylethyl)azetidin-3-ol

There total 6 articles about 1-(1-Methylethyl)azetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Isopropyl-oxiranylmethyl-amine (6452-58-0) → 1-isopropyl-azetidin-3-ol (13156-06-4)

Guidance literature:

With triethylamine; In acetonitrile; for 17h; Heating;

DOI:10.1081/SCC-120026859

Reference yield:

1-Isopropyl-3-trimethylsilanyloxy-azetidine (111043-40-4) → 1-isopropyl-azetidin-3-ol (13156-06-4)

Guidance literature:

With sodium methylate; In methanol; for 2h; Ambient temperature;

Reference yield:

3-isopropylamino-2-hydroxy-1-chloropropane (50666-68-7) → 1-isopropyl-azetidin-3-ol (13156-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: petroleum ether / 2 h / Heating

2: triethylamine / acetonitrile / 72 h / Heating

3: sodium methoxide; / methanol / 2 h / Ambient temperature

With sodium methylate; triethylamine; In methanol; acetonitrile; Petroleum ether;

upstream raw materials:

1-Isopropyl-3-trimethylsilanyloxy-azetidine

1,3-dichloro-2-(6-(3,4,5,6-tetrahydro-2H-pyranoxy))propane

isopropylamine

Isopropyl-oxiranylmethyl-amine

Downstream raw materials:

(1-isopropyl-azetidin-3-yl)-diphenyl-acetonitrile

Refernces

• 1、 Higgins, Robert H.,Eaton, Quentin L.,Worth, Leroy,Peterson, Myra V.. "Preparation of 3-Azetidinols with Non-Bulky 1-Alkyl Substituents ". . p. 255 - 259. Retrieved 2007/10/02.