2-(2,3-Difluoro-6-nitrophenyl)acetic acid

Base Information

• Chemical Name: 2-(2,3-Difluoro-6-nitrophenyl)acetic acid
• CAS No.: 141428-47-9
• Molecular Formula: C8H5F2NO4
• Molecular Weight: 217.129
• Hs Code.: 2916399090
• Mol file: 141428-47-9.mol

Synonyms:Benzeneacetic acid, 2,3-difluoro-6-nitro-;

Chemical Property of 2-(2,3-Difluoro-6-nitrophenyl)acetic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 154.0 to 158.0 °C
• Refractive Index: 1.553
• Boiling Point: 345.138 °C at 760 mmHg
• Flash Point: 162.534 °C
• PSA: 83.12000
• Density: 1.583 g/cm³
• LogP: 2.02330
• Storage Temp.: 2-8°C
• Solubility.: slightly sol. in Methanol

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,3-Difluoro-6-nitrophenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,3-Difluoro-6-nitrophenyl)acetic acid

There total 4 articles about 2-(2,3-Difluoro-6-nitrophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) + 2,3,4-trifluoronitrobenzene (771-69-7) → 2-(2,3-difluoro-6-nitrophenyl)acetic acid (141428-47-9)

Guidance literature:

sodium diethylmalonate; 2,3,4-trifluoronitrobenzene;

With hydrogenchloride; acetic acid; for 14h; Further stages.; Heating;

DOI:10.1016/j.bmcl.2007.09.013

Reference yield: 56.0%

→ 2-(2,3-difluoro-6-nitrophenyl)acetic acid (141428-47-9)

Guidance literature:

Reference yield:

2-(2,3-difluorophenyl)acetic acid (145689-41-4) → 2-(2,3-difluoro-6-nitrophenyl)acetic acid (141428-47-9) + (2,3-difluoro-5-nitrophenyl)acetic acid (875003-88-6)

Guidance literature:

With sulfuric acid; nitric acid; In water; at -10 - -5 ℃; for 0.25h;

upstream raw materials:

sodium diethylmalonate

2,3,4-trifluoronitrobenzene

2-(2,3-difluorophenyl)acetic acid

diethyl 2-(2,3-difluoro-4-nitrophenyl)malonate

Downstream raw materials:

3,4-difluoro-2-(2-hydroxyethyl)nitrobenzene

2,3-difluoro-4-nitrotoluene

1,2-difluoro-3-methyl-4-nitrobenzene

Refernces

• 1、 -. "BENZOXAZINONE AND BENZOXAZEPINONE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS". Page/Page column 36-37. . Retrieved 2010/11/28.
• 2、 -. "Oxazolidinones containing oxindoles as antibacterial agents". Page/Page column 17. . Retrieved 2008/06/13.