(E)-1-(2-Bromovinyl)-3-chlorobenzene

Base Information

• Chemical Name: (E)-1-(2-Bromovinyl)-3-chlorobenzene
• CAS No.: 115665-71-9
• Molecular Formula: C8H6BrCl
• Molecular Weight: 217.493
• Mol file: 115665-71-9.mol

Synonyms:(E)-β-bromo-3-chlorostyrene;(E)-1-(2-bromovinyl)-3-chlorobenzene;(E)-1-chloro-3-(2-bromovinyl)benzene;1-((E)-2-Bromo-vinyl)-3-chloro-benzene;

Chemical Property of (E)-1-(2-Bromovinyl)-3-chlorobenzene

Chemical Property:

• Boiling Point: 265.3 °C at 760 mmHg
• Flash Point: 126.6 °C
• PSA: 0.00000
• Density: 1.564 g/cm³
• LogP: 3.70560

Purity/Quality:

99% ^*data from raw suppliers

1-[2-Bromovinyl]-3-chlorobenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(2-Bromovinyl)-3-chlorobenzene

There total 9 articles about (E)-1-(2-Bromovinyl)-3-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-1-(3-chlorophenyl)ethylene → (E)-1-(2-bromovinyl)-3-chlorobenzene (115665-71-9)

Guidance literature:

With fluorescein; In 1,4-dioxane; at 20 ℃; for 24h; stereoselective reaction; Inert atmosphere; Irradiation;

DOI:10.1002/ejoc.201901119

Reference yield: 86.0%

m-Chlorocinnamic acid (1866-38-2,14473-90-6) → (Z)-1-(2-bromovinyl)-3-chlorobenzene (76557-95-4) + (E)-1-(2-bromovinyl)-3-chlorobenzene (115665-71-9)

Guidance literature:

With Selectfluor; potassium bromide; In water; acetonitrile; for 5h;

DOI:10.1021/jo048383x

Reference yield: 83.0%

m-Chlorocinnamic acid (1866-38-2,14473-90-6) → (E)-1-(2-bromovinyl)-3-chlorobenzene (115665-71-9)

Guidance literature:

With dibromamine-T; potassium carbonate; In acetonitrile; at 20 ℃; for 0.0833333h; stereoselective reaction;

DOI:10.1016/j.tetlet.2018.11.041

upstream raw materials:

m-Chlorocinnamic acid

m-Chlorobenzaldehyde

2-bromo-1-(3-chlorophenyl)ethanol

3-chlorocinnamic acid

Downstream raw materials:

(E)-3-chloro-β-iodostyrene

Refernces

• 1、 Larin, Egor M.,Lautens, Mark,Marchese, Austin D.,Mirabi, Bijan. "A Simplified Protocol for the Stereospecific Nickel-Catalyzed C-S Vinylation Using NiX 2 Salts and Alkyl Phosphites". . p. 311 - 319. Retrieved 2019/12/28.
• 2、 Chen, Xuenian,Gao, Yan,Jing, Yi,Ma, Yan-Na,Zhao, Qianyi. "Facile Synthesis of β-Bromostyrenes by Direct Bromination of Styrenes with N -Bromosuccinimide and Sodium Persulfate". supporting information. . Retrieved 2020/09/09.