N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride

Base Information

• Chemical Name: N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride
• CAS No.: 65797-42-4
• Molecular Formula: C15H23ClN2O
• Molecular Weight: 268.787
• Hs Code.: 2933399090
• European Community (EC) Number: 417-950-0,613-841-9
• DSSTox Substance ID: DTXSID201335103
• Mol file: 65797-42-4.mol

Synonyms:65797-42-4;N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride;N-(2',6'-Dinethylphenyl)-2-piperidinecarboxamide HCl;N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride;XUCXNUJDRBMBRF-UHFFFAOYSA-N;DTXSID201335103;2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-, monohydrochloride;MFCD09037377;N-(2',6'-DIMETHYLPHENYL)-2-PIPERIDINECARBOXAMIDE HYDROCHLORIDE;CS-0062468;EC 417-950-0;N-(2',6'-Dimethylphenyl)-2-piperidinecarboxamide HCl;N-(2,6-Dimethylphenyl)piperidine-2-carboxamidehydrochloride;N-(2',6'-Dinethylphenyl)-2-piperidinecarboxamide hydrochloride;N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1)

Chemical Property of N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride

Chemical Property:

• Melting Point: 267-268 °C(Solv: ethanol (64-17-5))
• PSA: 32.34000
• LogP: 3.61920
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 268.1342410
• Heavy Atom Count: 18
• Complexity: 257

Purity/Quality:

99.9% ^*data from raw suppliers

N-(2,6-Dimethylphenyl)piperidine-2-carboxamidehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-52/53
• Safety Statements: 22-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2.Cl

Technology Process of N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride

There total 2 articles about N-(2,6-Dimethylphenyl)piperidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (98303-20-9) → (+/-)-2',6'-pipecoloxylidide hydrochloride (65797-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroformic acid ethyl ester / tetrahydrofuran / 60 °C

2: hydrogenchloride / methanol / 3 h / 0 - 20 °C

With hydrogenchloride; chloroformic acid ethyl ester; In tetrahydrofuran; methanol;

Reference yield:

2,6-dimethylaniline (87-62-7) → (+/-)-2',6'-pipecoloxylidide hydrochloride (65797-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroformic acid ethyl ester / tetrahydrofuran / 60 °C

2: hydrogenchloride / methanol / 3 h / 0 - 20 °C

With hydrogenchloride; chloroformic acid ethyl ester; In tetrahydrofuran; methanol;

Reference yield: 80.0%

(+/-)-2',6'-pipecoloxylidide hydrochloride (65797-42-4) + ethyl iodide (75-03-6) → 1-ethyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide) (2180-94-1,98626-59-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

upstream raw materials:

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

2,6-dimethylaniline

Downstream raw materials:

ropivacaine hydrochloride

(S)-dibenzoyl-2-pipecolinoxylidide-L-tartrate

1-ethyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide)

Refernces

• 1、 -. "Method and using tracer charged ion channel". . . Retrieved 2018/08/20.