3-chloro-N-(3-chlorophenyl)propanamide

Base Information

• Chemical Name: 3-chloro-N-(3-chlorophenyl)propanamide
• CAS No.: 99585-98-5
• Molecular Formula: C9H9Cl2NO
• Molecular Weight: 218.083
• Hs Code.: 2924299090
• Mol file: 99585-98-5.mol

Synonyms:3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE;3-chloro-N-(3-chlorophenyl)propanamide(SALTDATA: FREE)

Chemical Property of 3-chloro-N-(3-chlorophenyl)propanamide

Chemical Property:

• Vapor Pressure: 4.08E-06mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 384.5 °C at 760 mmHg
• Flash Point: 186.3 °C
• PSA: 29.10000
• Density: 1.343 g/cm³
• LogP: 2.98040

Purity/Quality:

98%Min ^*data from raw suppliers

3-Chloro-N-(3-chlorophenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-N-(3-chlorophenyl)propanamide

There total 1 articles about 3-chloro-N-(3-chlorophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-chloro-aniline (108-42-9) + 2-chloropropionyl chloride (625-36-5) → 3-Chloro-N-(3-chlorophenyl)propanamide (99585-98-5)

Guidance literature:

With potassium carbonate; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield: 95.0%

1,2,3,4-tetrahydroisoquinoline (91-21-4) + 3-Chloro-N-(3-chlorophenyl)propanamide (99585-98-5) → 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-chlorophenyl)propanamide (428832-32-0)

Guidance literature:

With triethylamine; In acetonitrile; for 8h; Reflux;

DOI:10.1007/s12039-010-0018-7

Reference yield: 90.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 3-Chloro-N-(3-chlorophenyl)propanamide (99585-98-5) → N-(3-Chlorophenyl)-4-(2-methoxyphenyl)-1-piperazinopropanamide

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 6h; Heating;

upstream raw materials:

3-chloro-aniline

2-chloropropionyl chloride

Downstream raw materials:

N,N-diethyl-β-alanine-(3-chloro-anilide); hydrochloride

2,7-Dichloro-3-chloromethylquinoline

3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-chlorophenyl)propanamide

C₁₁H₁₁ClN₄OS

Refernces

• 1、 Ma, Liang,Pei, Heying,Lei, Lei,He, Linhong,Chen, Jinying,Liang, Xiaolin,Peng, Aihua,Ye, Haoyu,Xiang, Mingli,Chen, Lijuan. "Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases". supporting information. p. 178 - 190. Retrieved 2015/03/13.
• 2、 Swahn, Britt-Marie,Claesson, Alf,Pelcman, Benjamin,Besidski, Yevgeni,Molin, Hakan,Sandberg, Mats P.,Berge, Odd-Geir. "New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity". . p. 1635 - 1640. Retrieved 2007/10/03.