5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE

Base Information

• Chemical Name: 5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE
• CAS No.: 172349-10-9
• Molecular Formula: C6H6N2S.HCl
• Molecular Weight: 174.65
• Hs Code.: 2934999090
• Mol file: 172349-10-9.mol

Synonyms:5-AMINOMETHYL-THIOPHENE-2-CARBONITRILE;5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE;5-(Aminomethyl)-2-thiophenecarbonitrile hydrochloride;2-Thiophenecarbonitrile, 5-(aminomethyl)-, hydrochloride (1:1);2-Thiophenecarbonitrile, 5-(aMinoMethyl)-, Monohydrochloride

Chemical Property of 5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 301 °C at 760 mmHg
• Flash Point: 135.8 °C
• PSA: 78.05000
• LogP: 2.58078
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

5-Aminomethyl-thiophene-2-carbonitrile hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Aminomethyl)Thiophene-2-Carbonitrile Hydrochloride is a useful intermediate of oral thrombin inhibitor

Technology Process of 5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE

There total 7 articles about 5-(AMINOMETHYL)THIOPHENE-2-CARBONITRILE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-(N,N-Boc2-aminomethyl)thiophene-2-carbonitrile (201799-21-5) → 5-(aminomethyl)thiophene-2-carbonitrile hydrochloride (172349-10-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 0.166667h;

Reference yield:

iminodicarboxylic acid di-tert-butyl ester (51779-32-9) + ammonium chloride + 5-(bromomethyl)thiophene-2-carbonitrile (134135-41-4) → 5-(aminomethyl)thiophene-2-carbonitrile hydrochloride (172349-10-9)

Guidance literature:

With hydrogenchloride; NaH; In tetrahydrofuran; diethyl ether; ethyl acetate;

Reference yield:

iminodicarboxylic acid di-tert-butyl ester (51779-32-9) + ammonium chloride + 5-(bromomethyl)thiophene-2-carbonitrile (134135-41-4) → HO2 CCH2 -D-Cha-Pro-4-NHCH2 -2-amidinothiophene.HCl (N-(carboxymethyl)-D-cyclohexylalanyl-N-[[5-(aminoiminomethyl)thiophen-2-yl]methyl]-L-prolinamide hydrochloride) + 5-(aminomethyl)thiophene-2-carbonitrile hydrochloride (172349-10-9)

Guidance literature:

With hydrogenchloride; NaH; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

5-(N,N-Boc₂-aminomethyl)thiophene-2-carbonitrile

2-bromo-5-methyl thiophene

2-cyano-5-methylthiophene

5-(bromomethyl)thiophene-2-carbonitrile

Downstream raw materials:

N-benzylsulfonyl-D-leucyl-L-proline-[(5-cyano-2-thienyl)methyl]amide

Refernces

• 1、 -. "PEPTIDIC THROMBIN INHIBITOR COMPOUND". Page 19. . Retrieved 2010/02/06.
• 2、 -. "ANTITHROMBOTIC AGENTS". . . Retrieved 2008/06/13.