Magnesium, bromo[2-(phenylmethoxy)phenyl]-

Base Information

• Chemical Name: Magnesium, bromo[2-(phenylmethoxy)phenyl]-
• CAS No.: 328000-16-4
• Molecular Formula: C13H11BrMgO
• Molecular Weight: 287.439
• Hs Code.: 2931900090
• European Community (EC) Number: 628-699-3
• Mol file: 328000-16-4.mol

Synonyms:328000-16-4;MAGNESIUM, BROMO[2-(PHENYLMETHOXY)PHENYL]-;2-(Benzyloxy)phenylmagnesium bromide, 0.50 M in THF;2-(Benzyloxy)phenylmagnesium bromide, 0.50 M in 2-MeTHF;MFCD08705262;SCHEMBL1513410;VELKJPFZDYXBDE-UHFFFAOYSA-M;2-benzyloxyphenyl magnesium bromide;2-(Benzyloxy)phenylmagnesium bromide;2-(benzyloxy)phenyl magnesium bromide;(2-(Benzyloxy)phenyl)magnesium bromide;2-Benzyloxyphenylmagnesium bromide,1m &;2-Benzyloxyphenylmagnesium bromide, 0.25M 2-MeTHF

Chemical Property of Magnesium, bromo[2-(phenylmethoxy)phenyl]-

Chemical Property:

• Flash Point: -20 °C
• PSA: 9.23000
• Density: 1.047 g/mL at 25 °C
• LogP: 3.91140
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 285.98437
• Heavy Atom Count: 16
• Complexity: 265

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Benzyloxyphenylmagnesium bromide solution 1.0 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-14/15-19-34-40-37-14
• Safety Statements: 16-26-29-33-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC=[C-]2.[Mg+2].[Br-]
• Uses: 2-Benzyloxyphenylmagnesium bromide can be used:As a substrate in the iron-catalyzed coupling reaction of aryl Grignard reagents with unprotected bromophenols.As a substrate in the cross-coupling of Grignard reagents using diaryl titanates and ferric chloride.In one of the key synthetic steps for the total synthesis of an antibiotic caboxamycin.

Technology Process of Magnesium, bromo[2-(phenylmethoxy)phenyl]-

There total 1 articles about Magnesium, bromo[2-(phenylmethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromophenyl benzyl ether (31575-75-4) → (2-(benzyloxy)phenyl)magnesium bromide (328000-16-4)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield: 97.0%

C15H14F3N3O3 + (2-(benzyloxy)phenyl)magnesium bromide (328000-16-4) → C26H19F3N2O3

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield: 82.0%

benzyl benzo[d]oxazole-7-carboxylate + (2-(benzyloxy)phenyl)magnesium bromide (328000-16-4) → benzyl 2-(2-(benzyloxy)phenyl)benzo[d]oxazole-7-carboxylate

Guidance literature:

benzyl benzo[d]oxazole-7-carboxylate; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -40 ℃; for 1h;

(2-(benzyloxy)phenyl)magnesium bromide; With tbepc; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; oxygen; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c4cc08494b

upstream raw materials:

2-bromophenyl benzyl ether

Downstream raw materials:

2'-Benzyloxy-2-methoxyacetophenone

1-benzyl-4-(2-benzyloxy-phenyl)-piperidin-4-ol

4-(2-benzyloxy-phenyl)-2,6-diisopropyl-pyridine-3,5-dicarboxylic acid dimethyl ester

4-hydroxy-4-(2-hydroxyphenyl)piperidine

Refernces