4-Ethoxy-2,3-difluorophenol

Base Information

• Chemical Name: 4-Ethoxy-2,3-difluorophenol
• CAS No.: 126163-56-2
• Molecular Formula: C8H8F2O2
• Molecular Weight: 174.147
• Hs Code.: 29095000
• European Community (EC) Number: 678-797-5
• DSSTox Substance ID: DTXSID40560996
• Nikkaji Number: J2.971.493B
• Wikidata: Q72462906
• Mol file: 126163-56-2.mol

Synonyms:4-Ethoxy-2,3-difluorophenol;126163-56-2;1-Hydroxy-4-ethoxy-2,3-difluorobenzene;Phenol, 4-ethoxy-2,3-difluoro-;4-Ethoxy-2,3-difluorophenol, JRD;2,3-difluoro-4-ethoxyphenol;SCHEMBL423475;4-ethoxy-2,3-difluoro-phenol;AMY173;DTXSID40560996;PKIYFPSPIFCDDB-UHFFFAOYSA-N;4-Ethoxy-2,3-difluorophenol,JRD;MFCD07368025;AKOS006282952;CS-W017519;DS-5734;AC-14523;EN300-7406540;A851155

Chemical Property of 4-Ethoxy-2,3-difluorophenol

Chemical Property:

• Vapor Pressure: 0.0338mmHg at 25°C
• Melting Point: 73℃
• Refractive Index: 1.488
• Boiling Point: 234.8 °C at 760 mmHg
• PKA: 8.26±0.23(Predicted)
• Flash Point: 115.7 °C
• PSA: 29.46000
• Density: 1.273 g/cm³
• LogP: 2.06910
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 174.04923582
• Heavy Atom Count: 12
• Complexity: 143

Purity/Quality:

98.0%min ^*data from raw suppliers

4-Ethoxy-2,3-difluorophenol ^*data from reagent suppliers

Safty Information:

• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C(=C(C=C1)O)F)F

Technology Process of 4-Ethoxy-2,3-difluorophenol

There total 4 articles about 4-Ethoxy-2,3-difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

(4-ethoxy 2,3-difluorophenyl)boronic acid (212386-71-5) → 4-ethoxy-2,3-difluorophenol (126163-56-2)

Guidance literature:

(4-ethoxy 2,3-difluorophenyl)boronic acid; With dihydrogen peroxide; In water; at 20 - 25 ℃; for 2h;

With hydrogenchloride; In water; pH=6 - 7;

Reference yield: 71.0%

→ 3-(4-(trans-4-propylcyclohexyl)phenyl)-3,3-difluoropropionic acid 2,3-difluoro-4-ethoxyphenyl ester + 4-ethoxy-2,3-difluorophenol (126163-56-2)

Guidance literature:

Reference yield: 43.4%

→ 4-ethoxy-2,3-difluorophenol (126163-56-2)

Guidance literature:

upstream raw materials:

(4-ethoxy 2,3-difluorophenyl)boronic acid

Downstream raw materials:

C₁₉H₁₉Br

Refernces

• 1、 -. "Preparation method of 2, 3-difluoro-4-alkoxy phenol". Paragraph 0019. . Retrieved 2018/02/04.
• 2、 -. "Liquid crystal compound having negative dielectric anisotropy, liquid crystal composition containing said liquid crystal compound and liquid crystal display device using said composition". . . Retrieved 2008/06/13.