3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid

Base Information

• Chemical Name: 3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid
• CAS No.: 950604-93-0
• Molecular Formula: C9H8F4O2S
• Molecular Weight: 256.22
• Mol file: 950604-93-0.mol

Synonyms:3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid;2-Thiopheneacetic acid, 3-fluoro-α,α-dimethyl-5-(trifluoromethyl)-;2-[3-fluoro-5-(trifluoromethyl)-2-thienyl]-2-methylpropanecarboxylic acid

Chemical Property of 3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid

Chemical Property:

• PSA: 65.54000
• LogP: 3.26820

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid

There total 4 articles about 3-fluoro-a,a-dimethyl-5-(trifluoromethyl)-2-Thiopheneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-[5-(trifluoromethyl)-2-thienyl]propanecarboxylic acid (950604-92-9) → 2-[3-fluoro-5-(trifluoromethyl)-thiophen-2-yl]-2-methyl propanoic acid (950604-93-0)

Guidance literature:

2-methyl-2-[5-(trifluoromethyl)-2-thienyl]propanecarboxylic acid; With n-butyllithium; In tetrahydrofuran; hexane;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; hexane;

Reference yield:

ethyl 2-methyl-2-(2-thienyl)propanoate (666852-63-7) → 2-[3-fluoro-5-(trifluoromethyl)-thiophen-2-yl]-2-methyl propanoic acid (950604-93-0)

Guidance literature:

Multi-step reaction with 4 steps

1: N-iodo-succinimide / chloroform; acetic acid / 20 °C

2: copper(l) iodide / N,N-dimethyl-formamide / 95 °C

3: sodium hydroxide; water / ethanol / 20 °C

4: n-butyllithium / tetrahydrofuran; hexane

With sodium hydroxide; N-iodo-succinimide; n-butyllithium; water; copper(l) iodide; In tetrahydrofuran; ethanol; hexane; chloroform; acetic acid; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-(5-iodo-2-thienyl)-2-methylpropanoate (950604-88-3) → 2-[3-fluoro-5-(trifluoromethyl)-thiophen-2-yl]-2-methyl propanoic acid (950604-93-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 95 °C

2: sodium hydroxide; water / ethanol / 20 °C

3: n-butyllithium / tetrahydrofuran; hexane

With sodium hydroxide; n-butyllithium; water; copper(l) iodide; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;

upstream raw materials:

2-methyl-2-[5-(trifluoromethyl)-2-thienyl]propanecarboxylic acid

ethyl 2-methyl-2-(2-thienyl)propanoate

ethyl 2-(5-iodo-2-thienyl)-2-methylpropanoate

ethyl 2-methyl-2-[5-(trifluoromethyl)thiophen-2-yl] propanoate

Refernces