2-Amino-5-bromo-3-chloropyrazine

Base Information

• Chemical Name: 2-Amino-5-bromo-3-chloropyrazine
• CAS No.: 21943-13-5
• Molecular Formula: C4H3BrClN3
• Molecular Weight: 208.445
• Hs Code.: 2933990090
• Mol file: 21943-13-5.mol

Synonyms:2-Amino-5-Bromo-3-Chloropyrazine;5-Bromo-3-chloropyrazin-2-amine;5-bromo-3-chloropyrazin-2-amine;

Chemical Property of 2-Amino-5-bromo-3-chloropyrazine

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 128℃
• Refractive Index: 1.66
• Boiling Point: 271.288 °C at 760 mmHg
• PKA: 0.81±0.10(Predicted)
• Flash Point: 117.871 °C
• PSA: 51.80000
• Density: 1.961 g/cm³
• LogP: 2.05590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-3-chloropyrazin-2-amine ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-bromo-3-chloropyrazine

There total 3 articles about 2-Amino-5-bromo-3-chloropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.57%

3-amino-6-bromo-pyrazine-2-carboxylic acid (486424-37-7) → 2-amino-5-bromo-3-chloropyrazine (21943-13-5)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 45 - 60 ℃; for 0.00191667h; Temperature;

Reference yield: 75.0%

3-chloropyrazin-2-amine (6863-73-6) → 2-amino-5-bromo-3-chloropyrazine (21943-13-5)

Guidance literature:

With Selectfluor; lithium bromide; In N,N-dimethyl-formamide; at 30 ℃; for 24h; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c9ob00972h

Reference yield:

→ 2-amino-5-bromo-3-chloropyrazine (21943-13-5)

Guidance literature:

2-Amino-3-chlorpyrazin, Br2;

upstream raw materials:

3-chloropyrazin-2-amine

3-amino-6-bromo-pyrazine-2-carboxylic acid

Downstream raw materials:

5-bromo-3-chloropyrazin-2-ol

5-bromo-3-(methylthio)pyrazin-2-amine

Refernces

• 1、 -. "Synthesis method of 2-amino-3, 5-dihalogenated pyrazine". Paragraph 0041-0050. . Retrieved 2021/08/11.
• 2、 Caldwell, John J.,Veillard, Nicolas,Collins, Ian. "Design and synthesis of 2(1H)-pyrazinones as inhibitors of protein kinases". . p. 9713 - 9728,16. Retrieved 2012/12/11.