2-Amino-5-chloro-3-methoxypyrazine

Base Information

• Chemical Name: 2-Amino-5-chloro-3-methoxypyrazine
• CAS No.: 874-31-7
• Molecular Formula: C5H6ClN3O
• Molecular Weight: 159.575
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80444943
• Wikidata: Q82263231
• Mol file: 874-31-7.mol

Synonyms:2-Amino-5-chloro-3-methoxypyrazine;874-31-7;5-chloro-3-methoxypyrazin-2-amine;5-Chloro-3-methoxypyrazin-2-ylamine;SCHEMBL1732310;DTXSID80444943;LUJZVKRORABUDS-UHFFFAOYSA-N;AMY28622;MFCD11520878;AKOS006323879;AB64255;DS-0523;5-CHLORO-3-METHOXY-2-PYRAZINAMINE;CS-0094450;FT-0752440;EN300-198802;Q-103319

Chemical Property of 2-Amino-5-chloro-3-methoxypyrazine

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 128-131 °C
• Refractive Index: 1.585
• Boiling Point: 271.113 °C at 760 mmHg
• PKA: 2.01±0.10(Predicted)
• Flash Point: 117.765 °C
• PSA: 61.03000
• Density: 1.398 g/cm³
• LogP: 1.30200
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 159.0199395
• Heavy Atom Count: 10
• Complexity: 113

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-chloro-3-methoxypyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=CN=C1N)Cl

Technology Process of 2-Amino-5-chloro-3-methoxypyrazine

There total 4 articles about 2-Amino-5-chloro-3-methoxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sodium methylate (124-41-4) + 3-bromo-5-chloro-2-aminopyrazine (76537-18-3) → 2-amino-5-chloro-3-methoxypyrazine (874-31-7)

Guidance literature:

In methanol; for 6h; Heating;

DOI:10.1021/jm9604585

Reference yield: 69.0%

sodium methylate (124-41-4) + 3,5-dichloro-pyrazin-2-ylamine (873-42-7) → 2-amino-5-chloro-3-methoxypyrazine (874-31-7)

Guidance literature:

In methanol; at 20 - 70 ℃; for 16h;

Reference yield:

→ 2-amino-5-chloro-3-methoxypyrazine (874-31-7) + 5-dimethylamino-N-(5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide (173253-74-2)

Guidance literature:

upstream raw materials:

sodium methylate

3-bromo-5-chloro-2-aminopyrazine

3,5-dichloro-pyrazin-2-ylamine

Downstream raw materials:

5-dimethylamino-N-(5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide

Refernces

• 1、 -. "Heterocyclic compounds". . . Retrieved 2008/06/13.
• 2、 Bradbury, Robert H.,Bath, Colin,Butlin, Roger J.,Dennis, Michael,Heys, Christine,Hunt, Sarah J.,James, Roger,Mortlock, Andrew A.,Sumner, Neil F.,Tang, Eric K.,Telford, Berwick,Whiting, Elaine,Wilson, Campbell. "New non-peptide endothelin-a receptor antagonists: Synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N- pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1- naphthalenesulfonamides". . p. 996 - 1004. Retrieved 2007/10/03.