diethyl α-bromo-4-bromobenzylphosphonate

Base Information

• Chemical Name: diethyl α-bromo-4-bromobenzylphosphonate
• CAS No.: 23755-79-5
• Molecular Formula: C₁₁H₁₅Br₂O₃P
• Molecular Weight: 386.02
• Mol file: 23755-79-5.mol

Synonyms:

Chemical Property of diethyl α-bromo-4-bromobenzylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl α-bromo-4-bromobenzylphosphonate

There total 3 articles about diethyl α-bromo-4-bromobenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[bromo-(4-bromo-phenyl)-trimethylsilanyl-methyl]-phosphonic acid diethyl ester → diethyl α-bromo-4-bromobenzylphosphonate (23755-79-5)

Guidance literature:

With lithium ethoxide; In ethanol; at 0 ℃; for 0.25h; Yield given;

DOI:10.1016/S0040-4020(99)00037-X

Reference yield:

diethyl (4-bromobenzyl)phosphonate (38186-51-5) → diethyl α-bromo-4-bromobenzylphosphonate (23755-79-5)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane;

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → diethyl α-bromo-4-bromobenzylphosphonate (23755-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h / 100 °C

2: 1.) n-BuLi, HMDS, 2.) BrCl₂C-CCl₂Br / 1.) hexane, THF, -78 deg C -> 20 deg C; 20 deg C, 15 min, 2.) THF, -78 deg C, 15 min; -78 deg C -> 0 deg C

3: EtOLi / ethanol / 0.25 h / 0 °C

With n-butyllithium; 1,2-dibromo-1,1,2,2-tetrachloroethane; lithium ethoxide; 1,1,1,3,3,3-hexamethyl-disilazane; In ethanol;

DOI:10.1016/S0040-4020(99)00037-X

upstream raw materials:

diethyl (4-bromobenzyl)phosphonate

1-bromomethyl-4-bromobenzene

Refernces