2-Thiophenecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, ethyl ester

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, ethyl ester
• CAS No.: 1190235-26-7
• Molecular Formula: C14H11F3O2S
• Molecular Weight: 300.301
• Mol file: 1190235-26-7.mol

Synonyms:2-THIOPHENECARBOXYLIC ACID,5-[3-(TRIFLUOROMETHYL)PHENYL]-,ETHYL ESTER;

Chemical Property of 2-Thiophenecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, ethyl ester

Chemical Property:

• PSA: 54.54000
• LogP: 4.61060

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, ethyl ester

There total 1 articles about 2-Thiophenecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 5-bromothiophene-2-carboxylate (5751-83-7) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → ethyl 5-[3-(trifluoromethyl)phenyl]thiophene-2-carboxylate (1190235-26-7)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 68.0%

ethyl 5-[3-(trifluoromethyl)phenyl]thiophene-2-carboxylate (1190235-26-7) → {5-[3-(trifluoromethyl)phenyl]thiophen-2-yl}methanol (1190235-27-8)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

upstream raw materials:

ethyl 5-bromothiophene-2-carboxylate

(meta-(trifluoromethyl)phenyl)boronic acid

Downstream raw materials:

{5-[3-(trifluoromethyl)phenyl]thiophen-2-yl}methanol

Refernces