5-Bromopentanoic acid, t-butyl ester

Base Information

• Chemical Name: 5-Bromopentanoic acid, t-butyl ester
• CAS No.: 88987-42-2
• Molecular Formula: C9H17BrO2
• Molecular Weight: 237.137
• Mol file: 88987-42-2.mol

Synonyms:5-Bromopentanoic acid,t-butyl ester;

Chemical Property of 5-Bromopentanoic acid, t-butyl ester

Chemical Property:

• Boiling Point: 93 °C(Press: 1.6 Torr)
• PSA: 26.30000
• Density: 1.223±0.06 g/cm3(Predicted)
• LogP: 2.89330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

tert-Butyl5-Bromovalerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 5-Bromovalerate is a reactant used in synthetic preparation of haptens for production of monoclonal antibodies for pyraclostrobin ELISA.

Technology Process of 5-Bromopentanoic acid, t-butyl ester

There total 6 articles about 5-Bromopentanoic acid, t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromopentanoic acid (2067-33-6) + isobutene (115-11-7,15220-85-6) → tert-butyl 5-bromovalerate (88987-42-2)

Guidance literature:

With sulfuric acid; at 20 ℃; for 5h;

DOI:10.1021/ol006076h

Reference yield: 82.0%

5-bromopentanoic acid (2067-33-6) + tert-butyl alcohol (75-65-0) → tert-butyl 5-bromovalerate (88987-42-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

Reference yield:

tert-butyl alcohol (75-65-0) → tert-butyl 5-bromovalerate (88987-42-2)

Guidance literature:

5-bromopentanoic acid; With trifluoroacetic anhydride; In tetrahydrofuran; at -40 ℃; for 0.5h;

tert-butyl alcohol; In tetrahydrofuran; at -40 - 20 ℃; for 3h;

upstream raw materials:

5-bromopentanoic acid

isobutene

tert-butyl alcohol

2-tert-butyl-1,3-diisopropylisourea

Downstream raw materials:

7-tert-butyl 1-ethyl 2-pimelate

4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid benzyl ester

5-{(S)-3-(4-Chloro-phenyl)-4-[(R)-1-(4-chloro-phenyl)-ethyl]-2,5-dioxo-7-phenyl-2,3,4,5-tetrahydro-[1,4]diazepin-1-yl}-pentanoic acid tert-butyl ester

5-{(S)-7-(2-Bromo-phenyl)-3-(4-chloro-phenyl)-4-[(R)-1-(4-chloro-phenyl)-ethyl]-2,5-dioxo-2,3,4,5-tetrahydro-[1,4]diazepin-1-yl}-pentanoic acid tert-butyl ester

Refernces

• 1、 Steinebach, Christian,Kehm, Hannes,Lindner, Stefanie,Vu, Lan Phuong,K?pff, Simon,López Mármol, álvaro,Weiler, Corinna,Wagner, Karl G.,Reichenzeller, Michaela,Kr?nke, Jan,Gütschow, Michael. "PROTAC-mediated crosstalk between E3 ligases". supporting information. p. 1821 - 1824. Retrieved 2019/02/12.
• 2、 Pícha, Jan,Fabre, Benjamin,Budě?ínsky, Milo?,Hajduch, Jan,Abdellaoui, Mehdi,Jirá?ek, Ji?í. "Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides". supporting information. p. 5180 - 5192. Retrieved 2018/08/01.