6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one

Base Information

• Chemical Name: 6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one
• CAS No.: 614-65-3
• Molecular Formula: C13H12 N2 O
• Molecular Weight: 212.251
• Hs Code.: 2928000090
• Mol file: 614-65-3.mol

Synonyms:Benzaldehyde,2-hydroxy-, phenylhydrazone (9CI); Salicylaldehyde, phenylhydrazone(6CI,7CI,8CI); 2-Hydroxybenzaldehyde phenylhydrazone; NSC 68558; Phenyl2-[(2-hydroxy-1-phenyl)methylene]hydrazine; Salicylic aldehyde phenylhydrazone;o-Hydroxybenzaldehyde phenylhydrazone

Chemical Property of 6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one

Chemical Property:

• Vapor Pressure: 0.00159mmHg at 25°C
• Melting Point: 140-145oC
• Boiling Point: 294.7°C at 760 mmHg
• PKA: 8.51±0.35(Predicted)
• Flash Point: 110.1°C
• PSA: 44.62000
• Density: 1.302g/cm³
• LogP: 2.91120
• Solubility.: soluble in Acetone

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxybenzaldehyde phenylhydrazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one

There total 23 articles about 6-[(2-phenylhydrazinyl)methylidene]cyclohexa-2,4-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

salicylaldehyde (90-02-8) + phenylhydrazine (100-63-0) → 2-hydroxybenzaldehyde phenylhydrazone (614-65-3)

Guidance literature:

In water; ethyl acetate; at 20 ℃; for 0.00416667h;

Reference yield: 91.0%

2-methyl-benzyl alcohol (89-95-2) + phenylhydrazine (100-63-0) → 2-hydroxybenzaldehyde phenylhydrazone (614-65-3)

Guidance literature:

With Dowex resin acid form; In ethanol; for 0.833333h;

DOI:10.1080/00397910500184651

Reference yield: 66.0%

salicylaldehyde (90-02-8) + <18>Krone-6-Phenylhydrazin-1:2-Komplex (74885-89-5) → 2-hydroxybenzaldehyde phenylhydrazone (614-65-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

upstream raw materials:

phenylhydrazine hydrochloride

salicylaldehyde

ethanol

phenylhydrazine

Downstream raw materials:

3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one

salicylaldehyde semicarbazone

N-(2-hydroxy-α-phenylazo-benzyl)-hydrazine-N,N'-dicarboxylic acid diethyl ester

1,5-diphenyl-3-(o-hydroxyphenyl)formazan

Refernces

• 1、 Das, Diganta Kumar,Goswami, Priyanka,Sarma, Smita. "Salicylaldehyde phenylhydrazone: A new highly selective fluorescent lead (II) probe". . p. 503 - 508. Retrieved 2013.
• 2、 -. "METHODS OF FORMING IMINES, IMINE-RELATED AND IMINE-DERIVED COMPOUNDS USING GREEN SOLVENTS". Paragraph 0184-0185. . Retrieved 2021/10/22.
• 3、 Aguiar, Sandra I.,André, Ana S.,António, Jo?o P. M.,Bernardes, Gon?alo J. L.,Carvalho, Joana Inês,Dias, Joana N. R.,Faustino, Hélio,Gois, Pedro M. P.,Lopes, Ricardo M. R. M.,Veiros, Luis F.,da Silva, Frederico A.. "Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates**". supporting information. p. 25914 - 25921. Retrieved 2021/11/09.