Benzyl 4-(benzyloxy)-3-methoxybenzoate

Base Information

• Chemical Name: Benzyl 4-(benzyloxy)-3-methoxybenzoate
• CAS No.: 91203-74-6
• Molecular Formula: C22H20O4
• Molecular Weight: 348.398
• Mol file: 91203-74-6.mol

Synonyms:4-Benzyloxy-3-methoxybenzoic acid benzyl ester;Benzyl 4-(benzyloxy)-3-methoxybenzoate;

Chemical Property of Benzyl 4-(benzyloxy)-3-methoxybenzoate

Chemical Property:

• Vapor Pressure: 3.73E-10mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 500.6 °C at 760 mmHg
• Flash Point: 219 °C
• PSA: 44.76000
• Density: 1.174 g/cm³
• LogP: 4.63120

Purity/Quality:

98%Min ^*data from raw suppliers

BENZYL 4-(BENZYLOXY)-3-METHOXYBENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl 4-(benzyloxy)-3-methoxybenzoate

There total 2 articles about Benzyl 4-(benzyloxy)-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxy-4-hydroxybenzoic acid (121-34-6) + benzyl bromide (100-39-0) → 4-benzyloxy-3-methoxybenzoic acid benzyl ester (91203-74-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield: 95.0%

3-methoxy-4-hydroxybenzoic acid (121-34-6) + benzyl chloride (100-44-7) → 4-benzyloxy-3-methoxybenzoic acid benzyl ester (91203-74-6)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; Heating;

Reference yield: 100.0%

4-benzyloxy-3-methoxybenzoic acid benzyl ester (91203-74-6) → 4-benzyloxy-5-methoxy-2-nitrobenzoic acid benzyl ester (205259-40-1)

Guidance literature:

With nitric acid; acetic anhydride; at 20 ℃; for 3h;

DOI:10.1021/jm020505v

upstream raw materials:

3-methoxy-4-hydroxybenzoic acid

benzyl chloride

benzyl bromide

Downstream raw materials:

4-(benzyloxy)-3-methoxybenzoic acid

4-benzyloxy-5-methoxy-2-nitrobenzoic acid benzyl ester

7-benzyloxy-4-chloro-6-methoxyquinazoline

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

Refernces

• 1、 Xie, Yundong,Liu, Jiping,Shi, Yongheng,Bin Wang,Wang, Xiaoping,Wang, Wei,Sun, Meng,Xu, Xinya,He, Shipeng. "Synthesis and evaluation of new sesamol-based phenolic acid derivatives with hypolipidemic, antioxidant, and hepatoprotective effects". . p. 1688 - 1702. Retrieved 2021/07/26.
• 2、 Schwan, Gregor,Barbar Asskar, Ghadir,Hoefgen, Norbert,Kubicova, Lenka,Funke, Uta,Egerland, Ute,Zahn, Michael,Nieber, Karen,Scheunemann, Matthias,Straeter, Norbert,Brust, Peter,Briel, Detlef. "Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: Synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism". supporting information. p. 1476 - 1487. Retrieved 2014/07/21.