2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane

Base Information

• Chemical Name: 2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane
• CAS No.: 26103-07-1
• Molecular Formula: C4H3ClF6O
• Molecular Weight: 216.511
• Hs Code.: 2909199090
• UNII: RN4H73V5U3
• DSSTox Substance ID: DTXSID20436024
• Wikidata: Q72481710
• Mol file: 26103-07-1.mol

Synonyms:26103-07-1;2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane;PROPANE, 2-(CHLOROMETHOXY)-1,1,1,3,3,3-HEXAFLUORO-;chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether;RN4H73V5U3;chloromethyl hexafluoroisopropyl ether;Chloromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (Sevochlorane);1,1,1,3,3,3-Hexafluoro-2-chloromethoxypropane;chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether;Ether, chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl;2-(chloromethoxy)-1,1,1,3,3,3-hexafluoro-propane;(CF3)2CHOCH2Cl;UNII-RN4H73V5U3;SCHEMBL1025771;AMY6855;DTXSID20436024;BBL101902;MFCD09952406;STL555699;AKOS016009706;FS-4171;1,1,1,3,3,3-hexafluoro(2-chloromethoxy) propane;chloromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether;J-016256;Chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether

Chemical Property of 2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane

Chemical Property:

• Vapor Pressure: 52.835mmHg at 25°C
• Refractive Index: 1.31
• Boiling Point: 94.979 °C at 760 mmHg
• Flash Point: 11.244 °C
• PSA: 9.23000
• Density: 1.488 g/cm³
• LogP: 2.69250
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 215.9776614
• Heavy Atom Count: 12
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

ChloromethylHexafluoroisopropylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(OC(C(F)(F)F)C(F)(F)F)Cl

Technology Process of 2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane

There total 11 articles about 2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + formaldehyde di[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] acetal → 1,1,1,3,3,3-hexafluoroisopropyl chloromethyl ether (26103-07-1)

Guidance literature:

With thionyl chloride; sulfuric acid; at 15 - 35 ℃;

Reference yield: 93.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) → 1,1,1,3,3,3-hexafluoroisopropyl chloromethyl ether (26103-07-1)

Guidance literature:

1,1,1,3',3',3'-hexafluoro-propanol; With aluminum (III) chloride; In acetonitrile; at 0 - 10 ℃; for 0.333333h; Inert atmosphere;

formaldehyd; In acetonitrile; at 15 ℃; for 6h; Temperature; Inert atmosphere;

Reference yield: 90.6%

C7H3F13O2 → 1,1,1,3,3,3-hexafluoroisopropyl chloromethyl ether (26103-07-1)

Guidance literature:

With 1,3,5-Trioxan; aluminum (III) chloride; at 10 ℃; for 12h; Temperature; Concentration;

upstream raw materials:

1,1,1,3,3,3-hexafluoro-2-methoxypropane

1,3,5-Trioxan

1,1,1,3',3',3'-hexafluoro-propanol

sevoflurane

Downstream raw materials:

1,1,1,3',3',3'-hexafluoro-propanol

sevoflurane

bis-1,3-(1,1,1,3,3,3-hexafluoroiso-propoxymethyl)imidazolium chloride

1-(1,1,1,3,3,3-hexafluoroisopropoxy-methyl)-3-methylimidazolium chloride

Refernces

• 1、 Ramakrishna, Kornpati,Behme, Chris,Schure, Ralph M.,Bieniarz, Christopher. "A safe and efficient process for the synthesis of the inhalation anesthetic sevoflurane". . p. 581 - 584. Retrieved 2000.
• 2、 -. "Preparation method of chloromethyl hexafluoroisopropyl ether". Paragraph 0023; 0024; 0027; 0028. . Retrieved 2018/11/03.
• 3、 -. "Method for recycling sevoflurane impurity F(1)". Paragraph 0023; 0024; 0025; 0026; 0027; 0028-0038. . Retrieved 2017/07/22.