Technology Process of (R)-2-(Isopropoxy-dimethyl-silanyl)-1-((2R,3S,4S,5S,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-ethanol
There total 2 articles about (R)-2-(Isopropoxy-dimethyl-silanyl)-1-((2R,3S,4S,5S,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
at 0 ℃;
for 2h;
- Guidance literature:
-
With
1,1-Dibromoethane; magnesium;
Multistep reaction;
1) THF, reflux, 2) 2 h, 0 deg C;
DOI:10.1016/0008-6215(90)80133-N
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 3.7 g / 30percent H2O2, NaHCO3 / methanol; tetrahydrofuran / 15 h / Heating
2: pyridine / 0 deg C to r. t., overnight
3: 0.41 g / pyridine, 4-dimethylaminopyridine / 0.5 h
4: 82 percent / H2 / 10percent Pd-C / ethyl acetate / 24 h / 3000.2 Torr
5: p-toluenesulfonic acid / acetonitrile / 0.5 h / Ambient temperature
6: pyridine, 4-dimethylaminopyridine / acetonitrile / 1 h
7: 0.58 g / 90percent aq. trifluoroacetic acid / acetonitrile / 0.5 h
8: halide-assisted
9: 92 percent / aq. 70percent acetic acid / 36 h / Ambient temperature
10: silver trifluoromethanesulfonate, 2,4,6-trimethylpyridine
With
pyridine; 2,4,6-trimethyl-pyridine; dmap; hydrogen; dihydrogen peroxide; silver trifluoromethanesulfonate; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; acetonitrile;
DOI:10.1016/0008-6215(90)80133-N