5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID

Base Information

• Chemical Name: 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID
• CAS No.: 874509-45-2
• Molecular Formula: C₅H₄BrNO₂S
• Molecular Weight: 222.062
• Mol file: 874509-45-2.mol

Synonyms:5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID;5-broMo-4-Methylthiazole-2-carboxylic acid

Chemical Property of 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.55E-06mmHg at 25°C
• Boiling Point: 376°C at 760 mmHg
• Flash Point: 181.2°C
• PSA: 78.43000
• Density: 1.895
• LogP: 1.91220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-Bromo-4-methylthiazole-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID

There total 3 articles about 5-BROMO-4-METHYL-2-THIAZOLECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dibromo-4-methylthiazole (79247-78-2,170172-38-0) + carbon dioxide (124-38-9,18923-20-1) → 5-bromo-4-methyl-thiazole-2-carboxylic acid (874509-45-2)

Guidance literature:

2,5-dibromo-4-methylthiazole; With n-butyllithium; In hexane; at -70 ℃; for 1h;

carbon dioxide; In hexane;

Reference yield:

5-bromo-4-methyl-thiazole-2-carbonitrile (859481-85-9) → 5-bromo-4-methyl-thiazole-2-carboxylic acid (874509-45-2)

Guidance literature:

With ammonium hydroxide; at 110 ℃;

Reference yield:

5-bromo-4-methyl-thiazole-2-carboxylic acid amide (859480-77-6) → 5-bromo-4-methyl-thiazole-2-carboxylic acid (874509-45-2)

Guidance literature:

With ammonium hydroxide; at 110 ℃;

upstream raw materials:

5-bromo-4-methyl-thiazole-2-carbonitrile

5-bromo-4-methyl-thiazole-2-carboxylic acid amide

2,5-dibromo-4-methylthiazole

carbon dioxide

Downstream raw materials:

methyl 5-bromo-4-methylthiazole-2-carboxylate

Refernces