Isoquinoline-7-boronic acid

Base Information

• Chemical Name: Isoquinoline-7-boronic acid
• CAS No.: 1092790-21-0
• Molecular Formula: C9H8BNO2
• Molecular Weight: 172.979
• Mol file: 1092790-21-0.mol

Synonyms:Isoquinoline-7-boronic acid;

Chemical Property of Isoquinoline-7-boronic acid

Chemical Property:

• Boiling Point: 419.1 °C at 760 mmHg
• Flash Point: 207.3 °C
• PSA: 53.35000
• Density: 1.28 g/cm³
• LogP: -0.08540

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isoquinoline-7-boronic Acid shows strong fluorescent intensity changes upon sugar binding. Also, it is used in the discovery of inhibitor against Plasmodium falciparum HDACs.

Technology Process of Isoquinoline-7-boronic acid

There total 1 articles about Isoquinoline-7-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ isoquinolin-7-ylboronic acid (1092790-21-0)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

In diethyl ether; hexane; at -78 - 20 ℃;

Reference yield: 95.0%

isoquinolin-7-ylboronic acid (1092790-21-0) + tert-butyl 4-(4-(9-chloro-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate → 9-(isoquinolin-7-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

Guidance literature:

isoquinolin-7-ylboronic acid; tert-butyl 4-(4-(9-chloro-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos; In 1,4-dioxane; at 80 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 4.84%

isoquinolin-7-ylboronic acid (1092790-21-0) + (R)-N-((1-(3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamoyl)-2-chlorobenzenesulfonamide + trifluoroacetic acid (76-05-1) → (R)-2-chloro-N-((2-(3,5-difluorophenyl)-1-(3-(isoquinolin-7-yl)pyridin-2-yl)ethyl)carbamoyl)benzenesulfonamide bistrifluoroacetate

Guidance literature:

isoquinolin-7-ylboronic acid; (R)-N-((1-(3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamoyl)-2-chlorobenzenesulfonamide; With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

trifluoroacetic acid; In methanol; water;

Refernces