Technology Process of N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
There total 4 articles about N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 5 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide / 25 - 85 °C / Inert atmosphere
1.2: 0.5 h / 80 - 85 °C / Inert atmosphere
1.3: 25 - 30 °C / pH 1
2.1: hydrogenchloride; acetic acid / 2 h / 80 - 85 °C
3.1: thionyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 5 °C
With
hydrogenchloride; thionyl chloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 30 °C
2.1: sodium methylate / N,N-dimethyl-formamide / 25 - 85 °C / Inert atmosphere
2.2: 0.5 h / 80 - 85 °C / Inert atmosphere
2.3: 25 - 30 °C / pH 1
3.1: hydrogenchloride; acetic acid / 2 h / 80 - 85 °C
4.1: thionyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 5 °C
With
hydrogenchloride; thionyl chloride; sodium methylate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
