1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine

Base Information

• Chemical Name: 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine
• CAS No.: 478832-10-9
• Molecular Formula: C12H15N3O
• Molecular Weight: 217.271
• Hs Code.: 2934999090
• Mol file: 478832-10-9.mol

Synonyms:1H-Indazol-5-amine, 1-(tetrahydro-2H-pyran-2-yl)-;

Chemical Property of 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine

Chemical Property:

• Vapor Pressure: 1.49E-07mmHg at 25°C
• Refractive Index: 1.686
• Boiling Point: 428.7 °C at 760 mmHg
• Flash Point: 213.1 °C
• PSA: 53.07000
• Density: 1.36 g/cm³
• LogP: 2.89880

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-1-(tetrahydropyranyl)-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine

There total 3 articles about 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (150187-64-7) → 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine (478832-10-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; Inert atmosphere;

Reference yield:

5-nitroindazole (5401-94-5) → 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine (478832-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dichloromethane / 6 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In dichloromethane; ethyl acetate;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine (478832-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dichloromethane / 6 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In dichloromethane; ethyl acetate;

upstream raw materials:

5-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

5-nitroindazole

3,4-dihydro-2H-pyran

Downstream raw materials:

1-(4-((2-((1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)urea

1-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS". Paragraph 0550; 0552. . Retrieved 2015/07/27.
• 2、 -. "Rho KINASE INHIBITORS". Page 90. . Retrieved 2010/02/06.