5-Bromo-4-methylisoquinoline

Base Information

• Chemical Name: 5-Bromo-4-methylisoquinoline
• CAS No.: 651310-24-6
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 651310-24-6.mol

Synonyms:Isoquinoline, 5-bromo-4-methyl-;

Chemical Property of 5-Bromo-4-methylisoquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• Boiling Point: 331.462 °C at 760 mmHg
• PKA: 4.82±0.14(Predicted)
• Flash Point: 154.263 °C
• PSA: 12.89000
• Density: 1.488 g/cm³
• LogP: 3.30570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-methylisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-methylisoquinoline

There total 1 articles about 5-Bromo-4-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylisoquinoline (1196-39-0) → 5-bromo-4-methylisoquinoline (651310-24-6)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; at 0 ℃; for 2h;

Reference yield:

5-bromo-4-methylisoquinoline (651310-24-6) + (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid (312936-89-3) → 5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline (1454667-51-6)

Guidance literature:

5-bromo-4-methylisoquinoline; (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 80 ℃;

With platinum(IV) oxide; hydrogen; trifluoroacetic acid; In methanol; under 2327.23 Torr;

upstream raw materials:

4-methylisoquinoline

Downstream raw materials:

5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline

Refernces