3-(Chloromethyl)-5-methylpyridine hydrochloride

Base Information

• Chemical Name: 3-(Chloromethyl)-5-methylpyridine hydrochloride
• CAS No.: 1007089-84-0
• Molecular Formula: C₇H₈ClN*ClH
• Molecular Weight: 178.061
• Hs Code.: 2933399090
• Mol file: 1007089-84-0.mol

Synonyms:3-Chloromethyl-5-methylpyridine Hydrochloride

Chemical Property of 3-(Chloromethyl)-5-methylpyridine hydrochloride

Chemical Property:

• Boiling Point: 232.233 °C at 760 mmHg
• Flash Point: 116.576 °C
• PSA: 12.89000
• Density: 1.118 g/cm³
• LogP: 2.12880
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloromethyl-5-methylpyridine is an intermediate in the synthesis of Rupatadine (R701650).

Technology Process of 3-(Chloromethyl)-5-methylpyridine hydrochloride

There total 3 articles about 3-(Chloromethyl)-5-methylpyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

(5-methylpyridin-3-yl)methanol (102074-19-1) → 3-(chloromethyl)-5-methylpyridine hydrogen chloride (1007089-84-0)

Guidance literature:

With thionyl chloride; In 1,4-dioxane; at 25 - 70 ℃; for 4h; Temperature; Concentration;

Reference yield:

3,5-Lutidine (591-22-0) → 3-(chloromethyl)-5-methylpyridine hydrochloride (1007089-84-0)

Guidance literature:

3,5-Lutidine; With sulfuric acid; chlorine; In water; UV-irradiation; Industrial scale;

With hydrogenchloride; In water; Industrial scale;

Reference yield:

5-methylnicotinic acid methyl ester (29681-45-6) → 3-(chloromethyl)-5-methylpyridine hydrogen chloride (1007089-84-0)

Guidance literature:

With thionyl chloride; In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1016/j.bmcl.2007.11.101

upstream raw materials:

(5-methylpyridin-3-yl)methanol

5-methylnicotinic acid methyl ester

3,5-Lutidine

Refernces

• 1、 -. "Preparation method of rupatadine fumarate intermediate 5-methyl-3-chloromethylpyridine hydrochloride". Paragraph 0029-0032. . Retrieved 2021/07/17.
• 2、 -. "Synthesis method of rupatadine intermediate namely 3-chloromethyl-5-methylpyridine". Paragraph 0011. . Retrieved 2016/11/28.