Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)-

Base Information

• Chemical Name: Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)-
• CAS No.: 104160-22-7
• Molecular Formula: C₂₇H₂₈N₂O₅
• Molecular Weight: 460.53
• DSSTox Substance ID: DTXSID30146324
• Wikidata: Q83011123
• Mol file: 104160-22-7.mol

Synonyms:104160-22-7;Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)-;DTXSID30146324

Chemical Property of Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)-

Chemical Property:

• Vapor Pressure: 1.18E-21mmHg at 25°C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 460.19982200
• Heavy Atom Count: 34
• Complexity: 877

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)OC(=O)C7=CC=CC=C7N)O5)O
• Isomeric SMILES: C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)OC(=O)C7=CC=CC=C7N)O5)O

Technology Process of Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)-

There total 1 articles about Morphinan-6-one, 3-((2-aminobenzoyl)oxy]-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-, (5alpha)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

isatoic anhydride (118-48-9) + naltrexone (16590-41-3,91464-13-0) → naltrexone-3-anthranilate (104160-22-7)

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1002/jps.2600760503

upstream raw materials:

isatoic anhydride

naltrexone

Refernces