6-Bromo-2-chloropyridin-3-amine

Base Information

• Chemical Name: 6-Bromo-2-chloropyridin-3-amine
• CAS No.: 169833-70-9
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.46
• Hs Code.: 2933399090
• European Community (EC) Number: 696-449-0
• DSSTox Substance ID: DTXSID40365983
• Wikidata: Q82151028
• Mol file: 169833-70-9.mol

Synonyms:6-bromo-2-chloropyridin-3-amine;169833-70-9;3-Amino-6-bromo-2-chloropyridine;MFCD04971930;SCHEMBL857644;6-bromo-2-chloro-3-pyridinamine;DTXSID40365983;YCECOMBEVDPUJG-UHFFFAOYSA-N;6-bromo-2-chloro-3-pyridinylamine;6-Bromo-2-chloropyridine-3-ylamine;STL227624;AKOS000267429;AB20901;AM86685;CS-W003207;PS-5231;AC-27482;SY031476;A2967;FT-0733311;6-Bromo-2-chloropyridin-3-amine, AldrichCPR;EN300-81015;10.14272/YCECOMBEVDPUJG-UHFFFAOYSA-N.1;A811146;AC-907/34114024;doi:10.14272/YCECOMBEVDPUJG-UHFFFAOYSA-N.1;J-511661;F1926-0002

Chemical Property of 6-Bromo-2-chloropyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 117.0 to 121.0 °C
• Refractive Index: 1.648
• Boiling Point: 302.448 °C at 760 mmHg
• PKA: -0.07±0.10(Predicted)
• Flash Point: 136.716 °C
• PSA: 38.91000
• Density: 1.835 g/cm³
• LogP: 2.66090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 205.92464
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

98%, ^*data from raw suppliers

6-Bromo-2-chloropyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1N)Cl)Br

Technology Process of 6-Bromo-2-chloropyridin-3-amine

There total 2 articles about 6-Bromo-2-chloropyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

6-bromopyridine-3-amine (13534-97-9) → 6-bromo-2-chloropyridine-3-ylamine (169833-70-9)

Guidance literature:

With N-chloro-succinimide; acetic acid; at 90 ℃; for 2h;

Reference yield: 75.0%

2-chloro-3-aminopyridine (6298-19-7) → 6-bromo-2-chloropyridine-3-ylamine (169833-70-9)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide;

DOI:10.1021/ol051568l

Reference yield:

6-bromo-2-chloropyridine-3-ylamine (169833-70-9) → 6-bromo-2,3-dichloropyridine (1033820-08-4)

Guidance literature:

With copper dichloride; isopentyl nitrite; In acetonitrile; at 20 ℃; for 4h;

upstream raw materials:

2-chloro-3-aminopyridine

6-bromopyridine-3-amine

Downstream raw materials:

N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamide

6-bromo-2,3-dichloropyridine

5-bromothiazolo[5,4-b]pyridin-2-amine

5-bromo-2-chlorothiazolo[5,4-b]pyridine

Refernces

• 1、 -. "HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE". Page/Page column 210. . Retrieved 2020/01/24.
• 2、 Bacque, Eric,El Qacemi, Myriem,Zard, Samir Z.. "An unusual radical smiles rearrangement". . p. 3817 - 3820. Retrieved 2007/10/03.