3-Methoxy-5-methylphenylamine

Base Information

• Chemical Name: 3-Methoxy-5-methylphenylamine
• CAS No.: 66584-31-4
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• Mol file: 66584-31-4.mol

Synonyms:3-Methoxy-5-methylaniline;

Chemical Property of 3-Methoxy-5-methylphenylamine

Chemical Property:

• Melting Point: 46-47 °C
• Boiling Point: 257.7 °C at 760 mmHg
• PKA: 4.30±0.10(Predicted)
• Flash Point: 120.2 °C
• PSA: 35.25000
• Density: 1.039 g/cm³
• LogP: 2.16700
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxy-5-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxy-5-methylaniline is a aniline derivative used in the preparation of sulphonamides and aryl amines as antitubercular agents. 3-Methoxy-5-methylphenylamine is a aniline derivative used in the preparation of sulphonamides and aryl amines as antitubercular agents.

Technology Process of 3-Methoxy-5-methylphenylamine

There total 9 articles about 3-Methoxy-5-methylphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-hydroxy-4-methoxy-2-methylbenzene (5307-05-1) → 3-methoxy-5-methylphenylamine (66584-31-4)

Guidance literature:

1-hydroxy-4-methoxy-2-methylbenzene; With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane; In tetrahydrofuran; at 60 ℃; for 5h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 0.0833333h; pH=3 - 4;

DOI:10.1002/chem.201904987

Reference yield: 61.0%

2-Methoxy-4-methylphenol (93-51-6) → 3-methoxy-5-methylphenylamine (66584-31-4)

Guidance literature:

2-Methoxy-4-methylphenol; With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane; In tetrahydrofuran; at 60 ℃; for 5h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 0.0833333h; pH=3 - 4;

DOI:10.1002/chem.201904987

Reference yield: 58.0%

2-chloro-5-methylanisole (73909-16-7) → 3-methoxy-5-methylphenylamine (66584-31-4)

Guidance literature:

With iron(II) nitrate; ammonia; sodium; In acetone; for 2h; Heating;

DOI:10.1021/ol050769m

upstream raw materials:

3-methoxy-5-methyl-nitrobenzene

1-chloro-3-methoxy-5-methylbenzene

2-chloro-5-methylanisole

2-chloro-5-methylphenol

Downstream raw materials:

1-iodo-3-methoxy-5-methylbenzene

2-Amino-3-methoxy-5-methyl-benzaldehyd

2-Nitro-3-methoxy-5-methyl-benzaldehyd

3-Methoxy-5-methylpropiophenon

Refernces

• 1、 Elliott, Eric L.,Bushell, Simon M.,Cavero, Marta,Tolan, Brian,Kelly, T. Ross. "Total synthesis of nigellicine and nigeglanine hydrobromide". . p. 2449 - 2451. Retrieved 2007/10/03.