Enobosarm

Base Information Edit

Chemical Name:Enobosarm
CAS No.:841205-47-8
Deprecated CAS:1235370-13-4
Molecular Formula:C₁₉H₁₄F₃N₃O₃
Molecular Weight:389.334
Hs Code.:
UNII:O3571H3R8N
ChEMBL ID:CHEMBL1738889
DSSTox Substance ID:DTXSID30233006
Metabolomics Workbench ID:153131
NCI Thesaurus Code:C69161
Nikkaji Number:J2.977.571K
Wikidata:Q5379258
Wikipedia:Enobosarm
Mol file:841205-47-8.mol

Synonyms:(2S)-3-(4-cyanophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;enobosarm;GTx 024;GTx-024;MK 2866;MK-2866;MK2866;ostarine

Suppliers and Price of Enobosarm

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Ostarine
100 mg
$ 2400.00

Medical Isotopes, Inc.
Ostarine
10 mg
$ 675.00

DC Chemicals
Ostarine(MK-2286) >98%
100 mg
$ 200.00

ACHEMBLOCK
(S)-3-(4-Cyanophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide 95%
1G
$ 1550.00

ACHEMBLOCK
(S)-3-(4-Cyanophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide 95%
100MG
$ 300.00

ACHEMBLOCK
(S)-3-(4-Cyanophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide 95%
5MG
$ 65.00

Total 144 raw suppliers

Chemical Property of Enobosarm Edit

Chemical Property:

Boiling Point:632.3±55.0 °C(Predicted)
PKA:12.13±0.29(Predicted)
PSA：106.14000
Density:1.41±0.1 g/cm3(Predicted)
LogP:3.29026
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:389.09872580
Heavy Atom Count:28
Complexity:658

Purity/Quality:

99%, ^*data from raw suppliers

Ostarine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(COC1=CC=C(C=C1)C#N)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Isomeric SMILES:C[C@](COC1=CC=C(C=C1)C#N)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Recent ClinicalTrials:Study to Assess Long-Term Safety/Tolerability of Enobosarm (GTx 024) in Stress Urinary Incontinence
Recent EU Clinical Trials:ARTEST - A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Enobosarm Monotherapy Versus Active Control for the Treatment of AR+/ER+/HER2- Metastatic Breast Cancer in Patients with Androgen Receptor Nuclei Staining ≥40% Who Have Shown Previous Disease Progression on a Nonsteroidal Aromatase Inhibitor, Fulvestrant and CDK 4/6 inhibitor
description Ostarine, also known as MK-2866, is a selective androgen receptor modulator (SARM) that has been shown to be effective in helping people lose weight and build muscle mass. Ostarine works by binding to the androgen receptors in the body, which can help reduce body fat and increase muscle mass. It is non-toxic and has few side effects, making it a safe choice for those looking for an edge in the gym.
Uses Ostarine is nonsteroidal selective androgen receptor modulator (SARM) used in the treatment of osteoporosis and muscle wasting in animal models. A potential compound for the treatment of hypoactive sexual desire disorder.

Technology Process of Enobosarm

There total 5 articles about Enobosarm which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

: 767-00-0
4-cyanophenol

: 206193-17-1
(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

: 1235370-13-4,841205-47-8
Enobosarm

Guidance literature:: 4-cyanophenol; With sodium hydride; In tetrahydrofuran; mineral oil; Inert atmosphere;

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.04.052