2-BROMOBUTYRAMIDE

Base Information

• Chemical Name: 2-BROMOBUTYRAMIDE
• CAS No.: 5398-24-3
• Molecular Formula: C4H8BrNO
• Molecular Weight: 166.018
• Hs Code.: 2924199090
• Mol file: 5398-24-3.mol

Synonyms:Butyramide,2-bromo- (6CI,8CI);2-Bromobutanamide;2-Bromobutyramide;NSC 4597;

Chemical Property of 2-BROMOBUTYRAMIDE

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Melting Point: 112-113 °C
• Refractive Index: 1.496
• Boiling Point: 250.2 °C at 760 mmHg
• PKA: 14.86±0.50(Predicted)
• Flash Point: 105.1 °C
• PSA: 43.09000
• Density: 1.524 g/cm³
• LogP: 1.34550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromobutanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMOBUTYRAMIDE

There total 6 articles about 2-BROMOBUTYRAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-bromo-butyryl bromide (26074-52-2) → 2-bromobutyramide (5398-24-3)

Guidance literature:

With ammonium hydroxide; at -10 ℃;

DOI:10.1248/cpb.35.2243

Reference yield: 49.0%

butyric acid (107-92-6) → 2-bromobutyramide (5398-24-3)

Guidance literature:

DOI:10.1021/jo00170a043

Reference yield:

2-bromobutanoyl chloride (22118-12-3) → 2-bromobutyramide (5398-24-3)

Guidance literature:

With ammonium hydroxide; ammonia; at 0 ℃;

DOI:10.1021/ja01267a047

upstream raw materials:

2-bromobutyronitrile

2-bromobutanoyl chloride

2-bromo-butyryl bromide

2-bromobutyric acid ethyl ester

Downstream raw materials:

2-bromobutyronitrile

levetiracetam

2-(methylamino)butanamide

2-ethyl-4,4-diphenylbut-3-enamide

Refernces

• 1、 Chang, Xihao,Zhang, Qinglin,Guo, Chang. "Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination". supporting information. p. 4915 - 4918. Retrieved 2019/06/27.
• 2、 Freerksen, Robert W.,Selikson, Sandra J.,Wroble, Randall R.,Kyler, S. Keith,Watt, David S.. "Oxidative Decyanation of Secondary Nitriles to Ketones". . p. 4087 - 4096. Retrieved 2007/10/02.